Protozoan derived compositions and methods for treating autoimmune disease
AssigneeGovernment of the US, as represented by the Secretary, Department of Health and Human Services
InventorsJulio Aliberti, Jose Riberio, John Andersen, Hana Golding, Alan Sher
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Abstract
The instant invention relates to methods for treating a subject suffering from or susceptible to an autoimmune disease or disorder, or a disease or disorder having an autoimmune component, comprising administering to the subject an effective amount of cyclophilin or a biologically active fragment thereof.
Claims54
A method for treating a subject suffering from or susceptible to an autoimmune disease or disorder, or a disease or disorder having an autoimmune component, comprising administering to the subject an effective amount of cyclophilin or a biologically active fragment thereof.
A method of treating or preventing HIV infection in a subject comprising:
- administering to the subject an effective amount of a cyclophilin, or biologically active fragment thereof, wherein the cyclophilin is capable of inhibiting HIV infection of a cell;
- thereby treating or preventing HIV infection in a subject.
A method of inhibiting HIV infection of macrophages or T-cells comprising:
- contacting said macrophage or T-cell with an effective amount of a cyclophilin, cyclophilin, or biologically active fragment thereof, wherein the cyclophilin is capable of inhibiting HIV infection of a cell;
- thereby inhibiting the infection of macrophages or T-cells by HIV.
A pharmaceutical composition comprising cyclophilin, or a biologically active fragment thereof, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.