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US 2006/0148683 A1Published application
Detection and treatment of intravascular lesions
OwnerThomas McMurry, Robert Weisskoffinventors
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Abstract
Optical agents that contain a fibrin binding moiety covalently linked to an optical dye are described, as well as methods of treating intravascular lesions in a patient using such optical agents.
Claims50
A method for treating an intravascular lesion in a patient comprising:
- a) administering an optical agent, wherein the optical agent comprises a fibrin binding moiety and an optical dye, wherein the optical agent forms a fibrin-optical agent complex at the site of the lesion;
- b) detecting a signal from the fibrin-optical agent complex using a device inserted near the lesion;
- c) obtaining data about the lesion based on the signal from the fibrin-optical agent complex;
- and
- d) delivering a therapy to at least a portion of the lesion based on the obtained data.
2 more elements
A composition comprising an optical agent, wherein the optical agent comprises an optical dye covalently linked to the N-terminus of a peptide fibrin binding moiety (FBM) via a linker, said optical agent having the general formula:
A method to treat a thrombus in a blood vessel in a patient, said method comprising:
- a) administering an optical agent, said agent having the structure:
- to form a fibrin-optical agent complex;
- b) inserting a catheter in the blood vessel having said thrombus to obtain information about said thrombus, said information based on detecting a fluorescence emission signal of said fibrin-optical agent complex;
- and
- c) delivering with said catheter a thrombolytic therapy comprising tissue plasminogen activator (tPA) based on said information to about 90% of said thrombus so that the size of said thrombus is reduced.
2 more elements
Dependencies are inferred from the claim text.