Novel acyl-dipeptide-like compounds, a method for preparing the same and pharmaceutical compositions containing such products
AssigneeOm Pharma
InventorsJacques Bauer, Oliver Martin
Life of this patent
Estimating the term…
Abstract
The invention relates to the field of chemistry and more specifically to the field of medicinal chemistry. The invention is directed to N-acyl-dipeptide-like compounds having the general formula I wherein substituents A, B, X, Y, R1, R2, and subscripts n, m, p and q have the same meanings as those given in the claims. The invention is equally directed to pharmaceutical compositions containing as an active ingredient at least one compound of general formula I either in acid or salt form with an organic or mineral base. The compounds persuant to the invention display interesting pharmacological properties which make them useful as drugs.
Claims4
1-19. (canceled)
A diaminoalcohol of the formula:
- wherein R2 designates an acyl of a saturated or unsaturated carboxylic acid of 2 to 24 carbon atoms, which is unsubstituted or bears one member selected from the group consisting of hydroxyl, alkyl, alkoxy of 1 to 24 carbon atoms and alkyl thio of 1 to 24 carbon atoms and p and q are integers from 1 to 10.
A ω-hydroxy, ω-amino or ω-thio amino acid compound of the formula:
- wherein R1 is an acyl of a saturated carboxylic acid of 2 to 24 carbon atoms, which is unsubstituted or substituted with at least one member of the group consisting of hydroxyl, alkyl, alkoxy of 1 to 24 carbon atoms and alkyl thio of 1 to 24 carbon atoms
- m is an integer ranging from 1 to 10,
- n is an integer from 0 to 10,
- and X is an acid group which is optionally in an ester form selected from the group consisting of:
- carboxy [(C1-5)alkyl]
- CH—[(CH2)m1COOH][(CH2)n1COOH] with m1=0 to 5 and n1=0 to 5
- phosphono [(C1-5)alkyl]
- dihydroxyphosphonyloxy[(C1-5)alkyl]
- dimethoxyphosphonyl
- phosphono
- hydroxysulfonyl
- hydroxysulfonyl [(C1-5)alkyl] and
- hydroxysulfonyloxy [(C1-5)alkyl]
An ω-hydroxy, ω-amino acid compound of the formula:
- wherein R1 is an acyl of a saturated or unsaturated carboxylic acid having from 2 to 24 carbon atoms, which is unsubstituted or substituted with at least one member selected from the group consisting of hydroxyl, alkyl and alkoxy of 1 to 24 carbon atoms, amino, acyloxy of an organic carboxylic acid of 1 to 24 carbon atoms.
- m is an integer ranging from 1 to 10,
- n is an integer ranging from 0 to 10,
- and X is dialkyloxy- or diaryloxy-phosphoryl of the formula:
- wherein R is a group which readily undergoes clevage by hydrogenolysis.
Dependencies are inferred from the claim text.