Use of glucose-6-phosphate isomerase and antibodies thereto for the diagnosis and therapy of arthritis, and test of anti-arthritic compounds
AssigneeInstitut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsChristophe Benoist, Isao Matsumoto, Anne-Sophie Korganow, Diane Mathis, Mariana Maccioni, Hong Ji
Life of this patent
Estimating the term…
Abstract
The present invention relates to the use of antibodies against glucose-6-phosphate isomerase (GPI) and like protein for diagnosis of arthritis and the use of said protein for treatment of arthritis. It is also aimed at a process for isolating monoclonal antibodies capable of transferring arthritis and antibodies thereof, as well as a method for determining the anti-arthritis potential of a composition.
Claims2
A method for producing a non human arthritic mammal wherein arthritis has been induced by repeated injection of antibodies against glucose-6-phosphate isomerase (GPI) proteins,
A method for producing an arthritic mouse wherein arthritis has-been induced by repeated injection of antibodies against glucose-6-phosphate isomerase (GPI) proteins or of serum from arthritis K/B×N transgenic mice or fractions thereof.
Dependencies are inferred from the claim text.