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US 2006/0143721 A1Published application
Transgenic mice containing tryptase gene disruptions
OwnerKeith Allen, Michael Leviteninventors
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Abstract
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a tryptase gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
Claims1
A targeting construct comprising:
- (a) a first polynucleotide sequence homologous to a tryptase gene;
- (b) a second polynucleotide sequence homologous to the tryptase gene;
- and
- (c) a selectable marker.
1 more element
Dependencies are inferred from the claim text.