Tissue disorder imaging analysis
AssigneeThe General Hospital Corporation
InventorsGregory Sorensen, Nina Menezes, Hakan Ay
Life of this patent
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Abstract
Methods and systems are described for quantitatively determining a score (150) for a patient having a disorder, e.g., a stroke, in a tissue, such as the brain, by analyzing both the extent and location of damage (110, 120, 130 AND 140) to the tissue caused by the disorder.
Claims28
A hazard atlas of a disorder in a tissue comprising an image of the tissue, wherein the image comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location.
A system for determining a hazard score for a patient having a disorder in a tissue, comprising
- a device arranged to obtain or store an image of the patient's tissue, wherein the image comprises a plurality of patient image voxels;
- a memory or computer-readable medium storing a hazard atlas of a disorder in the tissue, wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location;
- an output device;
- and
- a processor linked to the imaging device, memory, and output device, wherein the processor is programmed to
- (i) obtain the image of a tissue of the patient;
- (ii) identify voxels of the patient image that are damaged by the disorder as damaged patient image voxels;
- (iii) obtain from the memory or computer-readable medium the hazard atlas of the disorder in the tissue;
- (iv) compute a hazard score for the patient, wherein the score is the integration of all damaged patient image voxels weighted by a hazard value corresponding to that voxel location;
- and
- (v) transmit the hazard score to the output device.
A method for determining a patient's hazard score for a disorder in a tissue, the method comprising:
- obtaining an image of a tissue of the patient, wherein the image comprises a plurality of patient image voxels;
- identifying voxels of the patient image that are damaged by the disorder as damaged patient image voxels;
- obtaining a hazard atlas of the disorder in the tissue;
- wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location;
- and
- computing a hazard score for the patient, wherein the score is the integration of all damaged patient image voxels weighted by a hazard value corresponding to that voxel location;
- wherein the hazard score determines the patient's prognosis.
A method of generating an expert hazard atlas, the method comprising:
- identifying one or more of anatomical, vascular, and functional regions on a standard set of anatomical images of a tissue;
- assigning weighting factors to the regions according to clinically-relevant assessment methodologies;
- and
- generating an expert hazard atlas of the tissue comprising a plurality of voxels based on the weighting factors for each voxel in the atlas.
A method of generating a data-driven hazard atlas, the method comprising:
- acquiring patient image data;
- matching patient image data to a standardized set of anatomical images;
- identifying regions of the patient's tissue with damage based on the image data;
- assigning weighting factors to the regions based on actual patient outcome data;
- and
- generating a data-driven hazard atlas of the tissue comprising a plurality of voxels based on the weighting factors for each voxel in the atlas.
A computer program for determining a hazard score of a patient having a disorder in a tissue, the program residing on a computer-readable medium and comprising instructions for causing a processor to:
- (a) obtain an image of a tissue of the patient, wherein the image comprises a plurality of patient image voxels;
- (b) identify voxels of the patient image that are damaged by the disorder as damaged image voxels;
- (c) obtain from a memory or computer-readable medium a hazard atlas of the disorder in the tissue, wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location;
- (d) compute a hazard score for the patient, wherein the score is the integration of all damaged patient image voxels weighted by a hazard value corresponding to that voxel location;
- wherein the hazard score determines the patient's prognosis;
- and
- (e) transmit the hazard score to an output device.
Dependencies are inferred from the claim text.