Microarray device for identifying splice variants of a gene
AssigneeJivan Biologics, Inc.
InventorsJonathan Bingham, Subha Srinivasan
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Abstract
A method and system for identifying mRNA present in a sample. A splice variant technique selects a set of possible exon-exon junctions based on exons of expected mRNA transcripts. The splice variant technique then selects indicator polynucleotides for the exon-exon junctions and detects the expression level of the indicator polynucleotides in the sample. The splice variant technique then may use a mathematical algorithm to identify possible splice variants in the sample from the observed expression levels.
Claims35
1-23. (canceled)
A nucleotide array, comprising:
- an indicator polynucleotide for a predicted exon-exon junction of a gene.
A nucleotide array, comprising:
- a first indicator polynucleotide for an exon-exon junction of a first splice variant of a gene and a second indicator polynucleotide for an exon-exon junction of a second splice variant of the gene.
A nucleotide array, comprising:
- a plurality of indicator polynucleotides for exon-exon junctions.
A nucleotide array comprising:
- an indicator polynucleotide for an exon-exon junction of a gene and a plurality of indicator polynucleotides for exons of the gene.
Dependencies are inferred from the claim text.