Devices for targeted delivery of thermotherapy, and methods related thereto
OwnerAllan Foreman, Wolfgang Dauminventors
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OwnerAllan Foreman, Wolfgang Dauminventors
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Disclosed are devices for targeted delivery of thermotherapy. These devices are useful in the treatment of diseased tissue in conjunction with magnetic compositions. Further disclosed are methods for treating diseased tissue, which involve the administration of a thermotherapeutic magnetic composition to a patient or a portion of a patient, and the application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. The devices and the methods disclosed herein are useful for the treatment of a variety of indications, such as cancer, diseases of the immune system, pathogen-borne diseases, hormone-related diseases, non-cancerous diseased cells or tissue, and undesirable matter, such as toxins and reaction-by-products associated with organ transplants.
1) A device for treating diseased tissue, comprising:
49). A method for treating diseased tissue in a patient, comprising:
50) A method according to claim 49, wherein the strength of the alternating magnetic field is sufficient to heat the magnetic particles to an effective temperature for treating the diseased tissue.
51) A method according to claim 49, wherein the poles of the magnetic circuit are shaped to influence the distribution of flux to maximize the field strength in the treatment area.
52) A method according to claim 49, wherein the poles of the magnetic circuit are canted at an angle to project magnetic flux outward into the treatment area without the patient being placed directly between them.
53) A method according to claim 49, wherein the magnetic circuit has one or more return paths.
54) A method according to claim 49, wherein the fundamental frequency of the alternating magnetic field is in the range of from about 100 kHz to about 500 kHz.
55) A method according to claim 49, wherein the alternating magnetic field has a sinusoidal fundamental waveform.
56) A method according to claim 49, wherein the alternating magnetic field has a non-sinusoidal fundamental waveform.
57) A method according to claim 49, wherein the alternating magnetic field has a fundamental waveform that is one of i) square wave, ii) trapezoidal and iii) sawtooth.
58) A method according to claim 49, wherein the alternating magnetic field is amplitude modulated with one of i) sinusoidal modulation, ii) a triangular modulation, iii) a square wave modulation, iv) a trapezoidal modulation and v) a sawtooth modulation, and vi) a combination of any of i)-v).
59) A method according to claim 49, wherein at least one of the fundamental frequency and the amplitude of the alternating magnetic field is modulated.
60) A method according to claim 49, wherein the alternating magnetic field is repetitively modulated having a pulse repetition frequency, the pulse repetition frequency being modulated.
61) A method according to claim 49, wherein the alternating magnetic field is generated by the one or more coils comprising a part of a resonant network.
62) A method according to claim 49, wherein the alternating magnetic field is generated by the one or more coils driven by an amplifier.
63) A method according to claim 49, wherein the alternating magnetic field is generated by the one or more coils driven by one or more pairs of pulse forming networks.
64) A method according to claim 49, further comprising monitoring of the amplitude of the magnetic field, wherein the monitoring result is used to modify or curtail the treatment.
65) A method according to claim 49, wherein the coils are combined with capacitors in series, in parallel, or a combination of series and parallel to form a resonant circuit.
68) A method according to claim 49, wherein the magnetic field strength is monitored at one or more locations to detect any local perturbations caused by magnetic or conductive materials in or near the treatment area.
69) A method according to claim 49, wherein the poles of the magnetic circuit are formed from pole pieces, the pole pieces being in an adjustable relationship with each other so that the size of the gap is adjustable.
70) A method according to claim 49, wherein the poles of the magnetic circuit are formed from removable pole pieces of selected shape.
71) A method according to claim 49, wherein the magnetic generator is liquid cooled.
72) A method according to claim 49, wherein the one or more coil turns are configured in series, in parallel, or a combination of series and parallel.
73) A method according to claim 49, wherein the one or more coil turns are located close to the gap.
74) A method according to claim 49, wherein the one or more coil turns are located away from the gap.
75) A method according to claim 49, wherein the coil turns have decreasing diameter causing the coil interior to have a conical shape.
76) A method according to claim 49, wherein the one or more coil turns comprise surface details, and wherein the surface details increase surface area of the coil.
77) A method according to claim 49, wherein one or more helper coils are located near the gap and operated in phase with the main coils.
79) A method according to claim 49, wherein a single-turn coil having a conical shape is used at each end of the magnetic circuit.
80) A method according to claim 49, wherein the one or more coils are cooled.
81) A method according to claim 49, further comprising targeting the region of the patient containing diseased cells utilizing a thermoplastic mask.
82) A method for treating diseased tissue, comprising iteratively adjusting one or more parameters of a treatment simulation to determine the optimal parameters for the treatment, wherein the heating of diseased tissue is maximized while the eddy current heating of healthy tissue is minimized.
84) A method according to claim 49, wherein the method is used in the treatment of cancer, diseases of the immune system, pathogen-borne diseases, hormone-related diseases, and undesirable matter, such as toxins, reaction-by-products associated with organ transplants, and other abnormal cell or tissue growth.
Dependencies are inferred from the claim text.