US 2006/0142701 A1Published application

Mixing syringe with and without flush

AssigneeInfusive Technologies, LLC

InventorsGale Thorne, Gale Thorne

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Abstract

A displaceable valved stopper is disclosed which partitions a conventional syringe into proximal and distal chambers to provide a multi-chamber, mixing syringe assembly. Also the valved stopper and a valve assembly are disclosed for use in a single conventional syringe to provide dual chamber mixing plus a disparate and sequentially dispensed flush. Incorporated in the valve assembly is another valved stopper and a separator which filters out gas from liquid being dispensed through the valve assembly. Each valved stopper is made as a single molded part which may be made from basic syringe plunger material. Also, each valved stopper may have a bi-state valve (e.g. a domed, slit valve). The separator is a single molded part which may be molded from basic syringe material. Each valve is actuated to a different state by differential pressure of a force greater than the associated valved stopper displacement force. A syringe plunger communicates through fluid in a more proximal chamber to force displacement of the valved stopper and valve assembly for both mixing and dispensing.

Claims28

Dependent claims

A mixing syringe apparatus for mixing and dispensing medical fluids, said apparatus comprising:

a syringe comprising a conventional hollow barrel having an elongated internal cylindrical surface, said barrel surface comprising an open proximal end and a distal end having a closed interior about an orifice through which fluid is transferred, and a stem and plunger combination, said combination being disposed to be displaced within said barrel by application of force in a predetermined direction against said stem thereby imposing predetermined differential pressures for displacing fluid within the barrel;
and
a removable cap which, in combination with said plunger, fully confines all fluid and material previously stored within said syringe barrel between the plunger and cap;
a displaceable valved stopper disposed within said barrel between said plunger and said distal end to provide a more proximal chamber disposed between the plunger and valved stopper as a container for a first volume of matter and a more distal chamber disposed between the distal end and valved stopper as a container for a second volume of matter, said first and second volumes of matter being kept disparate before mixing and mixed by action of force directed in the predetermined direction upon the stem of the syringe;
said displaceable valved stopper comprising a normally-closed valve which yields to an open state when the predetermined pressure differential is disposed across the valved stopper, the pressure differential causing diluting matter in a fluid state to be dispensed through the valve, thereby to mix the diluting fluid from the dispensing chamber with matter resident in the receiving chamber;
an elastic fluid disposed within the more distal chamber for storing energy resulting from pressure derived from force applied in the predetermined direction upon the stem of the syringe, at least a portion of the stored energy effecting displacement of the valved stopper in a direction opposite direction of the applied predetermined force, once that force is terminated, thereby changing size of one chamber relative to the other chamber and providing opportunity for additional dispensing of fluid through the valve by subsequent application of force in the predetermined direction.

3 more elements

A mixing syringe apparatus for mixing and dispensing medical fluids, said apparatus comprising:

a syringe comprising a conventional hollow barrel having an elongated internal cylindrical surface, said barrel surface comprising an open proximal end and a distal end having a closed interior about an orifice through which fluid is transferred, and a stem and plunger combination, said combination being disposed to be displaced within said barrel by application of force against said stem thereby imposing differential pressures for displacing fluid within the barrel;
and
a removable cap which, in combination with said plunger, fully confines all fluid and material previously stored within said syringe barrel between the plunger and cap;
a displaceable valved stopper disposed within said barrel between said plunger and said distal end to provide a more proximal chamber disposed between the plunger and valved stopper as a container for a medical material and a more distal chamber disposed between the distal end and valved stopper as a container for a diluting fluid which is to be mixed with the first medical material;
said displaceable valved stopper comprising;
a switchable bi-state valve comprising two operating states, a first state in which said valve is closed to fluid flow when disposed away from said distal end and imposed upon by a non-negative differential pressure but which is permissive to proximally directed fluid flow when imposed upon by a negative differential pressure and a second state in which said valve is permissive to distally directed flow resulting from a positive pressure gradient, said valve further comprising switchable construction which is displaced to a second state upon application of a predetermined positive differential pressure across the valved stopper.

3 more elements

A method for using a mixing syringe apparatus for mixing and dispensing medical fluids comprising the following steps:

(a) providing a syringe comprising a conventional hollow barrel having an elongated internal cylindrical surface, said barrel surface comprising an open proximal end and a distal end having a closed interior about an orifice through which fluid is transferred, and a stem and plunger combination, said combination being disposed to be displaced within said barrel by application of force against said stem thereby imposing differential pressures for displacing fluid within the barrel;
(b) providing a removable cap which, in combination with said plunger, fully confines all fluid and material previously stored within said syringe barrel between the plunger and cap;
(c) providing a displaceable valved stopper disposed within said barrel between said plunger and said distal end to provide a more proximal chamber disposed between the plunger and valved stopper as a container for a medical material and a more distal chamber disposed between the distal end and valved stopper as a container for a diluting fluid which is to be mixed with the first medical material;
said displaceable valved stopper comprising;
a switchable bi-state valve comprising two operating states, a first state in which said valve is closed to fluid flow when disposed away from said distal end and imposed upon by a non-negative differential pressure but which is permissive to proximally directed fluid flow when imposed upon by a negative differential pressure and a second state in which said valve is permissive to distally directed flow resulting from a positive pressure gradient, said valve further comprising switchable construction which is displaced to a second state upon application of a predetermined positive differential pressure across the valved stopper;
(d) placing a force on said stem to displace said stem and plunger proximally from an original site relative to said barrel thereby opening the valve of the valved stopper and displacing a portion of the fluid in the more distal chamber into the more proximal chamber;
(e) releasing the force from the stem, thereby permitting the valve to close, the stem and plunger to be displaced to the original site and the valved stopper to be distally displaced;
(f) repeating steps (d) and (e) until substantially all of the fluid originally resident in the more distal chamber is displaced from the more distal chamber to mix with material in the more proximal chamber and the valved stopper is displaced to the distal end of the barrel surface.

5 more elements

A method for using a mixing syringe apparatus for mixing and dispensing medical fluids comprising the following steps:

(a) providing a syringe comprising a conventional hollow barrel having an elongated internal cylindrical surface, said barrel surface comprising an open proximal end and a distal end having a closed interior about an orifice through which fluid is transferred, and a stem and plunger combination, said combination being disposed to be displaced within said barrel by application of force against said stem thereby imposing differential pressures for displacing fluid within the barrel;
(b) providing a removable cap which, in combination with said plunger, fully confines all fluid and material previously stored within said syringe barrel between the plunger and cap;
(c) providing a displaceable valved stopper disposed within said barrel between said plunger and said distal end to provide a more proximal chamber disposed between the plunger and valved stopper as a container for a diluting fluid and a more distal chamber disposed between the distal end and valved stopper as a container for a medical material which is to be mixed with the first medical material;
said displaceable valved stopper comprising;
a normally-closed valve;
said valve being disposed to open to permit flow of diluting fluid there through when imposed upon by a non-zero positive differential pressure but which closes when a non-positive differential pressure is imposed across the valved stopper whereby equilibrating pressure following a positive differential pressure disposed in chambers surrounding the valved stopper closes the valve, imposes a momentary non-positive pressure differential and thereby displaces the valved stopper proximally;
(d) placing a force on said stem to displace said stem and plunger distally from an original site relative to said barrel thereby opening the valve of the valved stopper and displacing a portion of the fluid in the more proximal chamber into the more distal chamber;
(e) releasing the force from the stem, thereby permitting the valve to close, the stem and plunger to be displaced to the original site and the valved stopper to be proximally displaced;
(f) repeating steps (d) and (e) until substantially all of the fluid originally resident in the more proximal chamber is displaced from the more proximal chamber to mix with material in the more distal chamber and the valved stopper is displaced to the abut the plunger.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 11/359,304Filed 21 Feb 2006
Priority: 3 May 2004
Published: 29 Jun 2006
Term ends: Not estimatedThe source records don’t support an estimate.

Classification4 codes

A61M 5/31596
Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing…:…
A61M 5/286
With sealing means to be broken or opened: upon internal pressure increase, e.g. pierced or burst
A61M 2005/3123
Details: having air entrapping or venting means, e.g. purging channels in pistons
A61M
Devices for delivering substances into the body

Family

Application10/838,101Continuation in part · filed 3 May 2004
Application11/284,504Continuation in part · filed 22 Nov 2005
Application11/359,304Continuation in part · filed 21 Feb 2006
US 2005/0245880 A1Published application
US 2006/0100590 A1Published application
US 6,997,910 B2Related patent
US 7,048,720 B1Related patent
US 7,101,354 B2Related patent
US 2006/0142701 A1This patent

From the US filing history. Foreign family members aren’t listed.