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US 2006/0142611 A1Published application
Preparation of 1,3-diphenylprop-2-en-1-one derivatives
AssigneeGenfit
InventorsJean-Francois Delhomel, Karine Caumont-Bertrand
Life of this patent
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Abstract
The invention relates to a method for the preparation of de 1,3-diphenylprop-2-en-1-one substituted on one of the two phenyl groups by a carboxyalkyloxy group or a carboxyalkylthio group.
Claims14
1-13. (canceled)
A method for preparing 1,3-diphenylprop-2-en-1-one derivatives substituted by a carboxyalkyloxy or carboxyalkylthio group, comprising the following steps:
- (i) contacting at least one 1,3-diphenylprop-2-en-1-one derivative substituted on one of the two phenyl groups by a hydroxyl or thiol group with at least one halogenated compound represented by general formula (II):
- in which Y represents a halogen atom, R is a C1-C24 alkyl chain and R′ is an acid-labile protective group of carboxylic acid;
- (ii) acid hydrolysis of the ester obtained in step (i).
Dependencies are inferred from the claim text.