Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
AssigneeNPS Pharmaceuticals, Inc.
InventorsAlan Mueller, Scott Moe
Life of this patent
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Abstract
Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits due to ischemia or hypoxia such as those that frequently occur as a consequence of cardiac surgery under cardiopulmonary bypass, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).
Claims23
(canceled)
A compound of the formula:
- wherein:
- X is independently selected from the group consisting of:
- —H, —Br, —Cl, —F, —I, —CF3, alkyl, —OH, —OCF3, —O-alkyl, and —O-acyl;
- R1 is independently selected from the group consisting of:
- —H, lower alkyl, and —O-acyl;
- R2 is independently selected from the group consisting of:
- —H, alkyl, and hydroxyalkyl, or both R2s together are imino;
- R4 is phenoxy which is optionally substituted with —F, —Cl, —Br, —I, —CF3, alkyl, —OH, —OCF3, —O-alkyl, or —O-acyl;
- provided that when X is H, then R4 is substituted with at least one of:
- meta-fluoro, meta-chloro, meta-methyl, meta-OH, ortho-fluoro, ortho-chloro, ortho-methyl, or ortho-OH;
- m is independently an integer from 1 to 5;
- and
- pharmaceutically acceptable salts and complexes thereof.
A compound of the formula:
- wherein:
- X is independently selected from the group consisting of:
- —H, —Br, —Cl, —F, —I, —CF3, alkyl, —OH, —OCF3, —O-alkyl, and —O-acyl;
- R1 is independently selected from the group consisting of:
- —H, lower alkyl, and —O-acyl;
- R2 is independently selected from the group consisting of:
- —H, alkyl, and hydroxyalkyl, or both R2s together are imino;
- R4 is phenoxy which is optionally substituted with —F, —Cl, —Br, —I, —CF3, alkyl, —OH, —OCF3, —O-alkyl, or —O-acyl;
- provided that when X is H, then R4 is substituted with at least one of:
- meta-fluoro, meta-chloro, meta-methyl, meta-OH, ortho-fluoro, ortho-chloro, or ortho-OH;
- m is independently an integer from 1 to 5;
- and
- pharmaceutically acceptable salts and complexes thereof.
A compound of the formula:
- wherein:
- X is —H;
- R1 is independently selected from the group consisting of:
- —H, lower alkyl, and —O-acyl;
- R2 is independently selected from the group consisting of:
- —H, alkyl, and hydroxyalkyl, or both R2s together are imino;
- R4 is phenoxy which is substituted with at least one of —F, —Br, —I, alkyl, —OH, —OCF3, or —O-acyl;
- and
- pharmaceutically acceptable salts and complexes thereof.
Dependencies are inferred from the claim text.