Back to results
US 2006/0142588 A1Published application
Acetoacetylation of alcohols, thiols and amines in a microreactor
OwnerUwe Nickel, Detlef Wehle +3inventors
InventorsUwe Nickel, Detlef Wehle, Leonhard Unverdorben, Klaus Forstinger, Hieng Kim
Life of this patent
Estimating the term…
Abstract
The invention relates to a method for the production of β-keto-carboxylic acid derivatives of formula (I) or the salts thereof, where X═NR′, O or S, R, R′, R1-R4 independently ═H, alkyl, alkenyl, aryl or heteroaryl, by reaction of a diketene of formula (II) with a compound comprising an active hydrogen of formula ROH, NHRR′ or RSH, characterised in that the reaction is continuously carried out in a microreactor.
Claims12
A process for preparing β-keto carboxylic acid derivative of the formula (I) or a salt thereof
- wherein
- X is NR′, O or S;
- R, R′ are each independently H, straight-chain, branched or cyclic alkyl or alkenyl having from 1 to 18 carbon atoms, aryl or heteroaryl, wherein one or more hydrogens in the alkyl, alkenyl, aryl and heteroalkyl radicals are optionally replaced by an inert substituent,
- R1, R2, R3 and R4 are each independently H, straight-chain, branched or cyclic alkyl or alkenyl having from 1 to 18 carbon atoms, aryl or heteroaryl, wherein one or more hydrogens in the alkyl, alkenyl, aryl and heteroalkyl radicals are optionally replaced by an inert substituent, or R1 and R2 and/or R3 and R4 are joined to one another and form methylene units of a cycloalkane ring —CH2—(CH2)k—CH2— where k=0, 1, 2, 3 or 4,
- comprising the step of reacting a diketene of the formula (II)
- with an active hydrogen-containing compound of the formula ROH, NHRR′ or RSH, and
- wherein the reacting step is carried out continuously in a microreactor.
4 more elements
Dependencies are inferred from the claim text.