Epothilone side components
AssigneeHelmholtz-Zentrum FüR Infektionsforschung GmbH
InventorsGerhard Hoefle, Hans Reichenbach, Klaus Garth, Ingo Hardt, Florenz Sasse, Heinrich Steinmetz
Life of this patent
Estimating the term…
Abstract
The invention concerns compounds which can be obtained by fermenting DSM 6773, especially epothilones A1, A2, A8, A9, B10, C1, C2, C3, C4, C5, C6, C7, C8, C9, D1, D2, D5, G1, G2, H1, H2, I1, I2, I3, I4, I5, I6 and K and trans-epothilones C1 and C2.
Claims15
1-13. (canceled)
An epothilone of the formula:
- wherein:
- for Epothilone C1 (16) R1=H;
- R2, R3, R4=methyl;
- R=H
- Epothilone D1 (17) R1=H;
- R2, R3, R4=methyl;
- R=methyl
- Epothilone C2 (18) R2=H;
- R1, R3, R4=methyl;
- R=H
- Epothilone D2 (19) R2=H;
- R1, R3, R4=methyl;
- R=methyl or
- Epothilone C3 (20) R3=H;
- R1, R2, R4=methyl;
- R=H
- said epothilone having a state of purity such as to be substantially free of Epothilone A and Epothilone B.
An epothilone of the formula:
- wherein:
- for Epothilone C5 (22) R=H or
- Epothilone D5 (23) R=methyl;
- said epothilone having a state of purity such as to be substantially free of Epothilone A and Epothilone B.
An epothilone of the formula:
- Epothilone C6 (24);
- said epothilone having a state of purity such as to be substantially free of Epothilone A and Epothilone B.
An epothilone of the formula:
- wherein:
- for Epothilone C7 (25) R7=OH;
- R8=methyl. or
- Epothilone C9 (27) R8=CH2OH;
- R7=H
- said epothilone having a state of purity such as to be substantially free of Epothilone A and Epothilone B.
An epothilone of the formula:
- wherein:
- for trans-Epothilone C1 (28) R1=H;
- R2=methyl or
- trans-Epothilone C2 (29) R1=methyl;
- R2=H;
- said epothilone having a state of purity such as to be substantially free of Epothilone A and Epothilone B.
24 An epothilone of the formula:
- wherein:
- for Epothilone I2 (31) R=H;
- R1, R2, R3=methyl
- Epothilone I3 (32) R1, R2, R3, R=methyl
- Epothilone I4 (33) R2, R=H;
- R1, R3=methyl
- Epothilone I5 (34) R2=H;
- R1, R3, R=methyl or
- Epothilone 16 (35) R1=H;
- R2, R3, R=methyl;
- said epothilone having a state of purity such as to be substantially free of Epothilone A and Epothilone B.
The epothilone according to claim 24, wherein said epothilone is substantially free of other major metabolic products produced by DSM6773.
An epothilone of the formula:
- Epothilone K (36);
- said epothilone having a state of purity such as to be substantially free of Epothilone A and Epothilone B.
Dependencies are inferred from the claim text.