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US 2006/0142583 A1Published application
Processes and intermediates for resolving piperidyl acetamide stereoisomers
AssigneeCelgene Corporation
InventorsVikram Khetani, Yalin Luo, Sowmianarayanan Ramaswamy
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Abstract
Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers.
Claims9
1-14. (canceled)
A synthetic process comprising the steps of:
- providing a mixture of said d,l-threo piperidyl acetamide stereoisomers having formulas:
- wherein R1 is aryl having about 6 to about 28 carbon atoms;
- reacting said stereoisomers with an acid resolving agent having the formula
- HO2CCH[OC(O)R3]CH[OC(O)R3]CO2H
- wherein each R3, independently, is aryl having 6 to about 28 carbon atoms or aralkyl having 7 to about 28 carbon atoms in an organic solvent comprising an alcohol, an alkyl alkanoate, a ketone, or an ether, and thereby forming acid salts;
- and
- physically isolating said acid salts.
4 more elements
Dependencies are inferred from the claim text.