Novel pyrimidineamide derivatives and the use thereof

A compound of formula 1

• wherein
• R1 represents hydrogen and R2 represents NR5R6, or R1 represents NR5R6 and R2 represents hydrogen;
• R3 represents lower alkyl, fluoroalkyl, hydroxyalkyl or carbamoyl;
• R4 represents hydrogen, lower alkyl or halogen;
• and
• R5 and R6 represent, independently of each other, hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, lower acyloxy-lower alkyl, carboxy-lower alkyl, lower alkoxycarbonyl-lower alkyl, amino-lower alkyl, lower alkylamino-lower alkyl, di(lower alkyl)amino-lower alkyl, N-lower alkylpiperidinyl, N-lower alkylpyrrolidinyl, or lower acyl, or R5R6 together represent alkylene with four, five or six carbon atoms, oxa-lower alkylene with one oxygen and three or four carbon atoms, or aza-lower alkylene with one nitrogen and three or four carbon atoms wherein the nitrogen atom is unsubstituted or substituted by lower alkyl, hydroxy-lower alkyl or lower alkoxy-lower alkyl, and wherein lower alkylene in each case may be partially or totally unsaturated and/or the carbon atoms of lower alkylene may be substituted by lower alkyl, hydroxy or lower alkoxy;
• and a N-oxide or a pharmaceutically acceptable salt of such a compound.