Process for the preparation of ganciclovir
OwnerJayachandra Babu, Purna Ray +2inventors
InventorsJayachandra Babu, Purna Ray, Chandra Khanduri, Yatendra Kumar
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Abstract
The present invention relates to a process for the preparation of N2-Acetyl-9-(1,3-diace-toxy-2-propoxymethyl) guanine, referred to here as N-9 alkylated isomer of structural formula I, and to the use of this compound as an intermediate for the preparation of antiviral compound, ganciclovir.
Claims23
A process for the preparation of N2-Acetyl-9-(1,3-diacetoxy-2-propoxymethyl)guanine of Formula I in pure form, the process comprising:
- obtaining a solution of N2-Acetyl-9-(1,3-diacetoxy-2-propoxymethyl) guanine in one or more solvents;
- and recovering the N2-Acetyl-9-(1,3-diacetoxy-2-propoxymethyl) guanine in pure form by the removal of the solvent.
N2-Acetyl-9-(1,3-diacetoxy-2-propoxymethyl)guanine having a purity of more than 98%.
N2-Acetyl-9-(1,3-diacetoxy-2-propoxymethyl)guanine having a purity of more than 98.5%.
N2-Acetyl-9-(1,3-diacetoxy-2-propoxymethyl)guanine having a purity of more than 98.8%.
N2-Acetyl-9-(1,3-diacetoxy-2-propoxymethyl)guanine containing less than 0.5% of monoacetyl and diacetyl guanine impurity.
N2-Acetyl-9-(1,3-diacetoxy-2-propoxymethyl)guanine having less than 0.15% of monoacetyl and diacetyl guanine impurity.
Dependencies are inferred from the claim text.