Back to results
US 2006/0142573 A1Published application
Method for producing L-biopterin
AssigneesShiratori Pharmaceutical Co., Ltd., Daiichi Suntory Pharma Co., Ltd.
InventorShinnosuke Tazawa
Life of this patent
Estimating the term…
Abstract
To provide a method for producing L-biopterin on a large industrial scale by using a reagent which is inexpensive and easy to handle, without requiring a use of any particular equipment or plants.
Claims13
A method for producing a biopterin derivative represented by the formula (6):
- wherein R1 and R2, which are the same or different from each other, each represents a hydrogen atom, an alkyl group, or an aryl group, comprising:
- reacting a compound belonging to triacetoxy-5-deoxy-L-arabinose phenylhydrazones represented by the formula (4):
- wherein R1 and R2 are the same as defined above,
- with 6-hydroxy-2,4,5-triaminopyrimidine (5) under catalytic influence of a Lewis acid in an aqueous solvent.
1 more element
A method for producing a 5-deoxy-L-arabinose hydrazone represented by the formula (3):
- wherein R1 and R2, which are the same or different from each other, each represents an hydrogen atom, an alkyl group, or aryl group, comprising:
- reacting 5-deoxy-L-arabinose with a hydrazine compound represented by the formula (2):
- wherein R1 and R2 are the same as defined above,
- under acidic conditions in water or an aqueous-organic two-layer solvent.
1 more element
Dependencies are inferred from the claim text.