Novel proteins and their uses
OwnerSongqing Na, Douglas Perkinsinventors
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Abstract
The present invention provides nucleic acid sequences encoding novel human proteins. These novel nucleic acids are useful for constructing the claimed DNA vectors and host cells of the invention and for preparing the claimed nucleic acids, recombinant proteins and antibodies that are useful in the claimed methods and medical uses.
Claims22
Isolated nucleic acid comprising DNA having at least 95% sequence identity to a polynucleotide selected from the group consisting of:
- (a) a polynucleotide having a nucleotide sequence as shown in SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, or 23;
- (b) a polynucleotide encoding a polyeptide having the amino acid sewuence as shown in SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, or 24;
- (c) a polynucleotide encoding the mature form of a polyeptide having the amino acid sequence as shown in SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, or 24;
- (d) a polynucleotide fragment of a polynucleotide as in (a), (b), or (c);
- and
- (e) a polynucleotide having a nucleotide sequence which is complementary to the nucleotide sequence of a polynucleotide as in (a), (b), (c), or (d).
An isolated nucleic acid molecule encoding a polypeptide comprising DNA that hybridizes to the complement of the nucleic acid sequence that encodes LP391, LP392, LP393, LP394, LP395, LP396, LP397, LP398, LP399, LP417, LP418, LP419 or any fragment or variant thereof.
An isolated polypeptide comprising an amino acid sequence comprising about 95% sequence identity to a sequence of amino acid residues comprising LP391, LP392, LP393, LP394, LP395, LP396, LP397, LP398, LP399, LP417, LP418, or LP419 as shown in SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, or 24, respectively.
An isolated polypeptide comprising a sequence of amino acid residues selected from the group consisting of:
- (a) SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, or 24;
- (b) fragments of (a) sufficient to provide a binding site for an LP polypeptide antibody;
- (c) extracellular domain of SEQ ID NO:2, 4, 6, 8, or 10;
- and
- (d) variants of (a), (b), or (c).
A chimeric molecule comprising an LP polypeptide fused to a heterologous amino acid sequence.
An antibody which specifically binds to an LP polypeptide.
A method of treating a mammal suffering from a disease, condition, or disorder associated with aberrant levels of an LP-polypeptide comprising administering a therapeutically effective amount of an LP polypeptide or LP polypeptide agonist.
A method of diagnosing a disease, condition, or disorder associated with aberrant levels of an LP polypeptide by:
- (1) culturing test cells or tissues expressing LP polypeptide;
- (2) administering a compound which can inhibit LP polypeptide modulated signaling;
- and (3) measuring the LP polypeptide-mediated phenotypic effects in the test cells or tissues.
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Dependencies are inferred from the claim text.