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US 2006/0142556 A1Published application
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
AssigneeIdera Pharmaceuticals, Inc.
InventorSudhir Agrawal
Life of this patent
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Abstract
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immunostimulatory effect for immunotherapy applications.
Claims2
-22. (canceled)
An immunostimulatory oligonucleotide having the structure
- 5′-Yn . . . Y6-Y5-Y4-Y3-Y2-Y1-CG-X1-X2-X3-X4-X5-
- X6-X7-X8-X9 . . . Xm-3′,
- wherein C is cytosine, G is 7-deazaguanosine, and each X and Y is independently a nucleoside or an immunomodulatory moiety, and n is a number from −6 to +20, and m is a number from −9 to +20.
Dependencies are inferred from the claim text.