Modulation of intracellular calcium signaling by N-acylethanolamines
AssigneeUniversity of North Texas Health Science Center
InventorsPeter Koulen, Kent Chapman
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Abstract
The present invention includes compositions and methods for neuroprotection by modulating intracellular calcium concentrations by administering an effective amount of an N-acylethanolamine to a subject.
Claims47
A composition that provides neuroprotection by modulating intracellular calcium concentrations when administered to a subject, the composition comprising an effective amount of an N-acylethanolamine.
A method for treating neurodegenerative conditions, the method comprising the step of administering to a subject in need thereof a composition comprising an effective amount of an N-acylethanolamine.
A method for treating ischemic cerebral trauma, the method comprising the step of administering to a subject in need thereof a composition comprising an effective amount of a plant-derived N-acylethanolamine.
A method for inhibiting apoptosis under ischemic conditions in an individual in need of such inhibition, the method comprising the step of administering to the individual an effective amount to inhibit apoptosis under ischemic conditions of a composition comprising at least one N-acylethanolamine and a pharmaceutically acceptable carrier.
A method for modulating the intracellular calcium concentration, comprising the step of administering to a cell an effective amount of at least one N-acylethanolamine.
A method of neuroprotection against ischemia, comprising administering to a subject an effective amount of at least one N-acylethanolamine to protect the cerebral cortex and the basal ganglia.
A compound that provides neuroprotection comprising the following formula:
- where:
- x is 1, 2, 3, 4, 5, 6 or more;
- and R is an alkyl, an aminoethanol or an aminoalcohol;
- and enantiomers thereof.
A compound that provides neuroprotection comprising the following formula:
- where:
- x is 1, 2, 3, 4, 5, 6;
- where:
- y is 1, 2, 3, 4, 5, 6;
- where R is an alkyl, an aminoethanol or an aminoalcohol;
- and enantiomers thereof.
A method for treating a condition in a subject, the method comprising the step of administering to a subject in need thereof a composition comprising an effective amount of a plant-derived N-acylethanolamine, wherein the conditions is selected from the group consisting of Alzheimer's disease, stroke, traumatic head and spinal cord injury, glaucoma, retinal ischemia, cardiac failure and ischemia and cancer.
A method for modulating an intracellular calcium channel of a neuronal cell in a host comprising determining the level of intracellular calcium channel signaling in the host and administering to the host a formulation containing an NAE, only if the level of signaling needs modulation.
Dependencies are inferred from the claim text.