Back to results
US 2006/0142387 A1Published application
Chemical compounds
OwnerRodolfo Cadilla, Andrew Larkin +3inventors
InventorsRodolfo Cadilla, Andrew Larkin, Eugene Stewart, Ryan Trump, Philip Turnbull
Life of this patent
Estimating the term…
Abstract
This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
Claims7
1-7. (canceled)
A compound of Formula (I)
- or a salt or solvate thereof, wherein
- R1 is cyano, nitro, halogen, haloalkyl, heterocyclyl, hydroxy, alkoxy, haloalkoxy, —OC(O)6, —CO2R6, —CONHR6, —C(O)R6, —S(O)nR6, —SO2N(R6)2, —NHC(O)R6, or —NHSO2R6;
- R2 is H, cyano, nitro, halogen, haloalkyl, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, haloalkoxy, —OC(O)R6, or aryl;
- R3 and R4 each are independently —(CH2)x—R5,
- where x is 0 to 6, and
- R5 is selected from H, alkyl, hydroxy, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, —C(O)OR7, or —N(R8)2;
- each R6 independently is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, or heteroaralkyl;
- each R7 independently is H, alkyl, cycloalkyl, aryl;
- each R8 independently is H or alkyl;
- and R9 is H, cyano, nitro, halogen, haloalkyl, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, haloalkoxy, —OC(O)R8, or aryl;
- and the compound is selected from:
- N-(cyclopropylmethyl)-N-(4-nitro-1-naphthyl)-N-propylamine;
- N-cyclohexyl-N-methyl-4-nitro-1-naphthalenamine;
- N-(4-nitro-1-naphthyl)-N,N-dipropylamine;
- N-butyl-N-methyl-N-(4-nitro-1-naphthyl)amine;
- 4-[ethyl(2-methyl-2-propenyl)amino]-1-naphthonitrile;
- N-butyl-N-ethyl-4-nitro-1-naphthalenamine;
- 4-[butyl(methyl)amino]-1-naphthonitrile;
- 4-[(cyclopropylmethyl)(propyl)amino]-1-naphthonitrile;
- N1-ethyl-N2,N2-dimethyl-N′-(4-nitro-1-naphthyl)-1,2-ethanediamine;
- 4-(propylamino)-1-naphthonitrile;
- 4-[(3-hydroxypropyl)amino]-1-naphthonitrile;
- 3-[(4-nitro-1-naphthyl)amino]propan-1-ol;
- 4-[(cyclopropylmethyl)amino]-1-naphthalenecarbonitrile;
- 4-{(cyclopropylmethyl)[3-(1-piperidinyl)propyl]amino}-1-naphthalene carbonitrile trifluoroacetate;
- 4-[(cyclopropylmethyl)(3-hydroxypropyl)amino]-1-naphthalenecarbonitrile;
- 4-nitro-N-(2,2,2-trifluoroethyl)-1-naphthalenamine;
- 4-bromo-N-(2,2,2-trifluoroethyl)-1-naphthalenamine;
- 4-bromo-N,N-bis(2,2,2-trifluoroethyl)-1-naphthalenamine;
- 4-[(2,2,2-trifluoroethyl)amino]-1-naphthalenecarbonitrile;
- 4-[bis(2,2,2-trifluoroethyl)amino]-1-naphthalenecarbonitrile;
- 4-[propyl(2,2,2-trifluoroethyl)amino]-1-naphthalenecarbonitrile;
- 4-[2-propen-1-yl(2,2,2-trifluoroethyl)amino]-1-naphthalenecarbonitrile;
- and
- 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-1-naphthalenecarbonitrile.
32 more elements
(canceled)
11-15. (canceled)
Dependencies are inferred from the claim text.