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US 2006/0142372 A1Published application
Benzofurane derivatives and the use the same as antidepressants and anxiolytics
AssigneeMerck Patent Gesellschaft
InventorsGunter Holzemann, Henning Bottcher, Kai Schiemann, Timo Heinrich, Joachim Leibrock, Christoph Van Amsterdam, Gerd Bartpszyk, Christoph Seyfried
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Abstract
Novel benzofuran derivatives of the formula (I) in which R1, R2, X, Y, Z and m have the meanings indicated in Patent Claim 1, they have a strong affinity to the 5-HT1A receptors. The compounds inhibit serotonin reuptake, exhibit serotonin-agonistic and -antagonistic properties and are suitable as antidepressants, anxiolytics, antipsychotics, neuroleptics and/or antihypertonics.
Claims16
Compounds of the formula I
- in which
- R1 denotes mono- or disubstitution by OH, OA, CN, Hal, COR or CH2R
- R denotes OH, OA, NH2, NHA or NA2
- R2 denotes H, A, Ar, CH2—Ar or CH2—OH
- A denotes alkyl having 1, 2, 3, 4, 5 or 6 atoms
- Z denotes CH2 or CO
- Y denotes a bond or CH2
- X denotes CH2OH, CH2OA or COR
- m denotes 2, 3, 4, 5 or 6,
- and pharmaceutically usable derivatives, solvates and stereoisomers thereof, including mixtures thereof in all ratios.
7 more elements
Dependencies are inferred from the claim text.