Azole derivatives and methods for making the same

A method of synthesizing the compound of the formula:

• wherein R is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyl, a substituted alkyne, a substituted aryl or an alkyl halide, alkoxy or aryloxy;
• adding a compound of the following formula which comprises:
• to a mixture comprised of a solvent to form a reaction mixture;
• and
• adding a carbonyl compound of the formula RCOCl wherein R is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyl, a substituted alkyne, a substituted aryl or an alkyl halide, alkoxy or aryloxy to the reaction mixture to produce (1).

A method of synthesizing a compound of the formula:

• wherein R1 of compound (2) is an alkyl, substituted alkyne y, or substituted aryl and wherein R2 of compound (2) is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyne, a substituted alkyl, an alkyl halide or a substituted aryl;
• which comprises:
• reacting a compound of the formula:
• wherein R1 is an alkyl, substituted alkyl, aryl, or substituted aryl
• in a first solution comprised of alcohol to form a compound of the formula
• wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl and wherein R2 is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyl, a substituted alkyne, an alkyl halide or a substituted aryl,
• adding compound (6) to a second solution comprised of a compound of the formula:
• and a coupling reagent to form a reaction mixture;
• and
• adding an oxidating reagent to the reaction mixture to produce compound (2) wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl and wherein R2 is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyl, a substituted alkyne, an alkyl halide or a substituted aryl.

A method of synthesizing a compound of the formula:

• wherein R1 of compound (2) is H and wherein R2 of compound (2) is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyl, a substituted alkyne, an alkyl halide or a substituted aryl;
• which comprises:
• reacting a compound of the formula:
• wherein R1 is an alkyl, substituted alkyl, aryl, or substituted aryl
• in a first solution comprised of alcohol to form a compound of the formula
• wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl and wherein R2 is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyne, a substituted alkyl, an alkyl halide or a substituted aryl,
• adding compound (6) to a second solution comprised of a compound of the formula:
• and a coupling reagent to form a reaction mixture;
• adding an oxidating reagent to the reaction mixture to produce compound (2) wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl and wherein R2 is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyne, a substituted alkyl, an alkyl halide or a substituted aryl;
• and
• cleaving the R1 of the compound (2) wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl and wherein R2 is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyl, a substituted alkyne, an alkyl halide or a substituted aryl with a base to produce the compound (2) wherein R1 is H and R2 is an alkyl, aryl, alkene, alkyne, a substituted alkene, a substituted alkyl, a substituted alkyne, an alkyl halide or a substituted aryl.

A method of synthesizing a compound of the formula:

• wherein X is O or NH which comprises:
• reacting a compound of the formula:
• wherein X is O or NH in a first solution comprised of solvent to produce a compound of the formula:
• wherein X is O or NH;
• reacting compound (8) in a second solution comprised of a solvent to produce a compound of the formula:
• wherein X═O or NH;
• and
• reacting a compound of the formula:
• with compound (9) to produce compound (4).