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US 2006/0142348 A1Published application
Aryl sulfonamide peri-substituted bicyclics for occlusive artery disease
AssigneedeCODE Chemistry, Inc.
InventorsJasbir Singh, Mark Gurney, Georgeta Hategan
Life of this patent
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Abstract
Aryl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is:
Claims36
A compound of formula
- wherein
- A and B represent a pair of fused 5-, 6- or 7-membered rings, said fused A/B ring system containing from zero to four heteroatoms chosen from nitrogen, oxygen and sulfur and said rings additionally substituted with from zero to four substituents chosen independently from halogen, —OH, loweralkyl, —O-loweralkyl, fluoroloweralkyl, —O-lowerfluoroalkyl, methylenedioxy, ethylenedioxy, alkoxy-loweralkyl, hydroxyloweralkyl, oxo, oxide, —CN, nitro, —S-loweralkyl, amino, loweralkylamino, diloweralkylamino, diloweralkylaminoalkyl, carboxy, carboalkoxy, acyl, carboxamido, loweralkylsulfoxide, acylamino, phenyl, benzyl, spirothiazolidinyl, phenoxy and benzyloxy;
- a and b represent points of attachment of residues Y and D respectively and a and b are in a peri relationship to one another on said fused A/B ring system;
- d and e represent points of fusion between ring A and ring B in said fused A/B ring system;
- D is an aryl or heteroaryl ring system, said ring system additionally substituted with from zero to four substituents chosen independently from halogen, —OH, loweralkyl, —O-loweralkyl, fluoroloweralkyl, —O-lowerfluoroalkyl, methylenedioxy, ethylenedioxy, alkoxy-loweralkyl, hydroxyloweralkyl, —CN, nitro, —S-loweralkyl, amino, loweralkylamino, diloweralkylamino, diloweralkylaminoalkyl, carboxy, carboalkoxy, acyl, carboxamido, loweralkylsulfoxide, acylamino, phenyl, benzyl, phenoxy and benzyloxy;
- Y is a linker comprising from zero to 8 atoms in a chain;
- M is chosen from aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, C6 to C20 alkyl and substituted C6 to C20 alkyl;
- R1 is chosen from aryl, substituted aryl, heteroaryl, substituted heteroaryl and CF3;
- and
- when Y is a single atom linker, R1 may additionally be lower alkyl.
7 more elements
A compound of formula
- wherein
- A and B represent a pair of fused 5-, 6- or 7-membered rings, said fused A/B ring system containing from zero to four heteroatoms chosen from nitrogen, oxygen and sulfur and said rings additionally substituted with from zero to four substituents chosen independently from halogen, —OH, loweralkyl, —O-loweralkyl, fluoroloweralkyl, —O-lowerfluoroalkyl, methylenedioxy, ethylenedioxy, alkoxy-loweralkyl, hydroxyloweralkyl, oxo, oxide, —CN, nitro, —S-loweralkyl, amino, loweralkylamino, diloweralkylamino, diloweralkylaminoalkyl, carboxy, carboalkoxy, acyl, carboxamido, loweralkylsulfoxide, acylamino, phenyl, benzyl, spirothiazolidinyl, phenoxy and benzyloxy;
- a and b represent points of attachment of residues Y and D respectively and a and b are in a peri relationship to one another on said fused A/B ring system;
- d and e represent points of fusion between ring A and ring B in said fused A/B ring system;
- U is C═O or P═O;
- D is an aryl or heteroaryl ring system, said ring system additionally substituted with from zero to four substituents chosen independently from halogen, —OH, loweralkyl, —O-loweralkyl, fluoroloweralkyl, —O-lowerfluoroalkyl, methylenedioxy, ethylenedioxy, alkoxy-loweralkyl, hydroxyloweralkyl, —CN, nitro, —S-loweralkyl, amino, loweralkylamino, diloweralkylamino, diloweralkylaminoalkyl, carboxy, carboalkoxy, acyl, carboxamido, loweralkylsulfoxide, acylamino, phenyl, benzyl, phenoxy and benzyloxy;
- Y is a linker comprising from zero to 8 atoms in a chain;
- M is chosen from aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, C6 to C20 alkyl and substituted C6 to C20 alkyl;
- R1 is chosen from aryl, substituted aryl, heteroaryl, substituted heteroaryl and CF3;
- and
- when Y is a single atom linker, R1 may additionally be lower alkyl.
8 more elements
Dependencies are inferred from the claim text.