S-lansoprazole compositions and methods
OwnerTimothy Barberich, William Yelle +1inventors
InventorsTimothy Barberich, William Yelle, Paul Rubin
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Abstract
Methods and compositions are disclosed utilizing optically pure (−) lansoprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of lansoprazole. The optically pure (−) isomer is also useful for the treatment of gastroesophageal reflux. (−) Lansoprazole is an inhibitor of H+ release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.
Claims18
1-12. (canceled)
A method of treating ulcers with lansoprazole which comprises administering to a human a therapeutically effective amount of optically pure S(−)isomer of lansoprazole, or a pharmaceutically acceptable salt thereof.
A method of treating gastroesophageal reflux disease which comprises administering to a human a therapeutically effective amount of optically pure S(−)isomer of lansoprazole, or a pharmaceutically acceptable salt thereof.
A method of treating a condition caused by or contributed to by gastric hypersecretion which comprises administering to a human a therapeutically effective amount of optically pure S(−)isomer of lansoprazole, or a pharmaceutically acceptable salt thereof.
A method of treating psoriasis which comprises administering to a human a therapeutically effective amount of optically pure S(−)isomer of lansoprazole, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.