Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht 4-antagonists

A compound of formula (I)

• a stereochemically isomeric form thereof, an N-oxide form thereof, or a pharmaceutically acceptable acid or base addition salt thereof, wherein
• —R1—R2— is a bivalent radical of formula
• —O—CH2—O— (a-1),
• —O—CH2—CH2— (a-2),
• —O—CH2—CH2—O— (a-3),
• —O—CH2—CH2—CH2— (a-4),
• —O—CH2—CH2—CH2—O— (a-5),
• —O—CH2—CH2—CH2—CH2— (a-6),
• —O—CH2—CH2—CH2—CH2—O— (a-7),
• —O—CH2—CH2—CH2—CH2—CH2— (a-8),
• wherein in said bivalent radicals optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C1-6alkyl or hydroxy,
• R3 is hydrogen, halo, C1-6alkyl or C1-6alkyloxy;
• R4 is hydrogen, halo, C1-6alkyl;
• C1-6alkyl substituted with cyano, or C1-6alkyloxy;
• C1-6alkyloxy;
• cyano;
• amino or mono or di(C1-6alkyl)amino;
• R5 is hydrogen or C1-6alkyl, and the —OR5 radical is situated at the 3- or 4-position of the piperidine moiety;
• L is a radical of formula
• -Alk-R6 (b-1),
• -Alk-X—R7 (b-2),
• -Alk-Y—C(═O)—R9 (b-3),
• -Alk-C(═O)—NH—C(═O)—R11 (b-4),
• -Alk-C(═O)—NH—SO2—R11 (b-5),
• -Alk-SO2—NH—C(═O)—R11 (b-6),
• -Alk-SO2—NH—SO2—R11 (b-7),
• wherein each Alk is C1-12alkanediyl;
• and
• R6 is aminosulfonyl optionally substituted with C1-4alkyl, C3-6cycloalkyl or phenyl;
• R7 is C1-6alkylsulfonyl;
• X is NR8;
• said R8 being C1-6alkyl;
• R9 is C1-6alkylsulfonylamino;
• Y is a O, S, or NR10 wherein R10 is hydrogen or C1-6alkyl;
• and
• R11 is C1-6alkyl or phenyl.