Piperidine derivative and use thereof
OwnerYoshinori Ikeura, Tadatoshi Hashimoto +3inventors
InventorsYoshinori Ikeura, Tadatoshi Hashimoto, Haruyuki Nishida, Junya Shirai, Nobuki Sakauchi
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Abstract
The present invention provides a compound represented by the formula: wherein Ar is an aryl group optionally having substituents, R is a C1-6 alkyl group, R1 is a hydrogen atom, a hydrocarbon group optionally having substituents, an acyl group or a heterocyclic group optionally having substituents, X is an oxygen atom or an imino group optionally having substituents, ring A is a piperidine ring optionally further having substituents, and ring B is a benzene ring having substituents, or a salt thereof, and an agent for the prophylaxis or treatment of lower urinary tract abnormality and the like, which contains the compound.
Claims20
A compound represented by the formula:
- wherein Ar is an aryl group optionally having substituent(s), R is a C1-6 alkyl group, R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group or a heterocyclic group optionally having substituent(s), X is an oxygen atom or an imino group optionally having a substituent, ring A is a piperidine ring optionally further having substituent(s), and ring B is a benzene ring having substituent(s), or a salt thereof.
(3R,4S)-4-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-phenyl-1-[[1-(1H-tetrazol-1-ylacetyl)piperidin-4-yl]carbonyl]piperidine,
- N-[trans-4-[[(3R,4S)-4-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenylpiperidin-1-yl]carbonyl]cyclohexyl]propanamide,
- 4-[[(3R,4S)-4-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenylpiperidin-1-yl]carbonyl]piperidine-2,6-dione,
- (3R,4S)-4-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-phenyl-1-{[1-(1H-1,2,4-triazol-1-ylacetyl)piperidin-4-yl]carbonyl}piperidine,
- (3R,4S)-4-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-phenyl-1-{[1-(1H-pyrazol-1-ylacetyl)piperidin-4-yl]carbonyl}piperidine, or a salt thereof.
Dependencies are inferred from the claim text.