Vanilloid receptor modulators

A compound of formula (I),

• or a pharmaceutically acceptable salt or solvate thereof, wherein,
• P is selected from phenyl, heteroaryl or heterocyclyl;
• R1 and R2 are independently selected from halo, alkyl, alkoxy, cycloalkyl, aralkyl, aralkoxy, cycloalkylalkyl, cycloalkylalkoxy, —CN, —NO2, —OH, ═O, —OCF3, —CF3, —NR4R5, —S(O)mR6, —S(O)2NR4R5, —OS(O)2R6, —OS(O)2CF3, —O(CH2)nNR4R5, —C(O)CF3, —C(O)alkyl, —C(O)cycloalkyl, —C(O)aralkyl, —C(O)Ar, —C(O)(CH2)nOR6, —C(O)(CH2)nNR4R5, —C(O)alkoxy, —C(O)NR4R5, —(CH2)nC(O)alkoxy, —(CH2)nOC(O)R6, —O(CH2)nOR6, —(CH2)nOR6, —(CH2)nR4R5, —(CH2)nC(O)NR4R5, —(CH2)nN(R4)C(O)R6, —(CH2)nS(O)2NR4R5, —(CH2)nN(R4)S(O)2R6, -ZAr, —(CH2)nS(O)2R6, —(OCH2)nS(O)2R6, —N(R4)S(O)2R6, —N(R4)C(O)R6, —(CH2)nN(R4)S(O)2R6, —(CH2)nN(R4)C(O)R6 or —(CH2)nC(O)alkyl;
• R3 is selected from alkyl, alkoxy, —CF3, halo, —O(CH2)nOR6, —O(CH2)nNR4R5, phenyl, cyclohexyl, benzo[1,3]dioxolyl, morpholinyl, pyridyl, pyrimidinyl, pyrazinyl, piperazinyl, piperidinyl, pyridizinyl, thienyl, furyl, pyrazolyl, pyrrolyl, triazolyl, indanyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, isothiazolyl, isoxazolyl or thiadiazolyl;
• wherein said alkyl, alkoxy, phenyl, cyclohexyl, benzo[1,3]dioxolyl, morpholinyl, pyridyl, pyrimidinyl, pyrazinyl, piperazinyl, piperidinyl, pyridizinyl, thienyl, furyl, pyrazolyl, pyrrolyl, triazolyl, indanyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, isothiazolyl, isoxazolyl and thiadiazolyl groups may be optionally substituted by one or more groups, which may be the same or different, selected from R2;
• R4 and R5 may be the same or different and represent —H or alkyl or R4 and R5 together with the nitrogen atom to which they are attached form a heterocyclic ring;
• R6 is —H, alkyl or aryl;
• R7 is —H, alkyl or aryl;
• R8 is selected from —H, alkyl, hydroxyalkyl, cycloalkyl, aralkyl, alkoxyalkyl, cycloalkylalkyl, heterocyclylalkyl, —S(O)mR6, —C(O)CF3, —C(O)alkyl, —C(O)cycloalkyl, —C(O)aralkyl, —C(O)Ar, —C(O)(CH2)nOR6, —C(O)(CH2)nNR4R5, —C(O)alkoxy, —C(O)NR4R5, —(CH2)nC(O)alkoxy, —(CH2)nOC(O)R6, —(CH2)nOR6, —(CH2)nR4R5, —(CH2)nC(O)NR4R5, —(CH2)nN(R4)C(O)R6, —(CH2)nS(O)2NR4R5, —(CH2)nN(R4)S(O)2R6, —(CH2)nS(O)2R6, —(CH2)nN(R4)S(O)2R6, —(CH2)nN(R4)C(O)R6 or —(CH2)nC(O)alkyl;
• or where X is NR8 and Y is C(R9)2, R8 may combine with R1 to form a benzoquinuclidine group;
• R9 is —H or R1;
• Ar is aryl or heteroaryl, each of which may be optionally substituted by R2;
• Z is a bond, O, S, NR7 or CH2;
• m is 0, 1 or 2;
• n is an integer value from 1 to 6;
• q and r are independently selected from 0, 1, 2 or 3;
• s is 0, 1, 2 or 3;
• and
• X and Y are selected such that:
• when X is N, Y is CR9;
• when X is NR8, Y is C(R9)2;
• when X is CR9, Y is N;
• when X is C(R9)2, Y is NR8;
• with the proviso that said compound of formula (I) is not a compound selected from:
• N-{3-[(N,N-Dimethylamino)methyl]-1,2,3,4-tetrahydro-7-quinolinyl}-4-biphenylcarboxamide;
• N-{3-[(N,N-Dimethylamino)methyl]-1-formyl-1,2,3,4-tetrahydro-7-quinolinyl}-4-biphenylcarboxamide;
• N-{1-Acetyl-3-[(N,N-dimethylamino)methyl]-1,2,3,4-tetrahydro-7-quinolinyl}-4-biphenylcarboxamide;
• N-{3-[(N,N-Dimethylamino)methyl]-1-methylsulfonyl-1,2,3,4-tetrahydro-7-quinolinyl}-4-biphenylcarboxamide;
• 5-amino-N-isoquinolin-5-yl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide;
• 5-methyl-N-quinolin-8-yl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide,
• 5-methyl-N-quinolin-7-yl-1-[3-trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide, 5-methyl-N-quinolin-3-yl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide,
• N-isoquinolin-5-yl-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide,
• 5-methyl-N-quinolin-5-yl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide,
• 1-(3-chlorophenyl)-N-isoquinolin-5-yl-5-methyl-1H-pyrazole-3-carboxamide,
• N-isoquinolin-5-yl-1-(3-methoxyphenyl)-5-methyl-1H-pyrazole-3-carboxamide,
• 1-(3-fuorophenyl)-N-isoquinolin-5-yl-5-methyl-1H-pyrazole-3-carboxamide,
• 1-(2-chloro-5-trifluoromethylphenyl)-N-isoquinolin-5-yl-5-methyl-1H-pyrazole-3-carboxamide,
• 5-methyl-N-(3-methylisoquinolin-5-yl)-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide, and
• 5-methyl-N-(1,2,3,4-tetrahydroisoquinolin-5-yl)-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide.