5-HT7 receptor antagonists

A compound of the formula I:

• wherein
• W is a substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl;
• R1, R2, R3, R4, R5, R6 and R7 are each independently selected from the group formed by hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, —COR8, —C(O)OR8, —C(O)NR8R9, —HC═NR8, —CN, —OR8, —OC(O)R8, —S(O), —R8, —NR8R9, —NR8C(O)R9, —NO2, —N═CR8R9 or halogen;
• wherein
• t is 1, 2 or 3;
• R8 and R9 are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, halogen;
• and the 1,2,3,4-tetrahydroisoquinoline group is linked through the methylene group to positions 3 or 4 of the piperidine ring;
• or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof.