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US 2006/0142321 A1Published application
5-HT7 receptor antagonists
OwnerAntoni Jover, Susana Yenes Minguez +4inventors
InventorsAntoni Jover, Susana Yenes Minguez, Jose Mas Prio, Luz Romero Alonso, Alberto Dordal Zueras, Helmut Buschmann
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Abstract
The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
Claims34
A compound of the formula I:
- wherein
- W is a substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl;
- R1, R2, R3, R4, R4B, R5, R5B, R6 and R7 are each independently selected from the group formed by hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, —COR8, —C(O)OR8, —C(O)NR8R9, —HC═NR8, —CN, —OR8, —OC(O)R8, —S(O)t—R8, —NR8R9, —NR8C(O)R9, —NO2, —N═CR8R9 or halogen;
- L is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, —COR8, —C(O)OR8, —C(O)NR8R9, —HC═NR8, —CN, —OR8, —OC(O)R8, —S(O)t—R8, —NR8R9, —NR8C(O)R9, or —N═CR8R9;
- and wherein the pair R4 and R4B or the pair R5 and R5B taken together may form a carbonyl group, t is 1, 2 or 3;
- R8 and R9 are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, halogen;
- n is 2, 3, 4 or 5;
- or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof.
5 more elements
Dependencies are inferred from the claim text.