Substituted biaryl piperazinyl-pyridine analogues

A compound according to Formula 1:

• wherein
• HET is selected from
• RA is independently selected at each occurrence of RA from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted haloalkyl, chloro, fluoro, hydroxy, amino, optionally substituted mono and di-alkylamino, and nitro;
• or
• two adjacent RA groups taken in combination form a group of the formula:
• which may be optionally substituted;
• R is L-(CR1R2)n—C(O)—X or a group of the formula:
• L is a single bond, an optionally substituted 1,2-vinylidene group, or a 1,2 acetylene-diyl group;
• X is selected from OH, SH, NH2, optionally substituted alkoxy, optionally substituted benzyloxy, or optionally substituted aryloxy and salts thereof;
• and
• Y is independently selected at each occurrence from the group consisting of —C(O)—X, hydrogen, methyl, ethyl, chloro, fluoro, hydroxy, amino, trifluoromethoxy, or methoxy, wherein at least one occurrence of Y is CO2H or a salt thereof;
• Z is a single bond or hydrocarbon chain having from 1 to about 6 carbon atoms in the chain and between 0 and about 2 double or triple bonds in the chain;
• n is an integer of from 0 to about 12, wherein the sum of n and the number of carbon atoms in the hydrocarbon chain of the Z group is greater than 0;
• i is an integer from 0 to about 4;
• j is an integer from 0 to about 5;
• and
• R1, R2, R3 are independently selected at each occurrence from the group consisting of hydrogen, methyl, ethyl, chloro, fluoro, hydroxy, amino, trifluoromethoxy, or methoxy.