C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones

A compound of the formula I:

• wherein:
• W is selected from the group consisting of NH, N(CO)R7, NR7, S, S(O), S(O)2, and halogen;
• R1 is hydrogen, C1-C6 alkyl, halogen, OR7, or NR7R8;
• R2 and R3 are independently selected from the group consisting of hydrogen, halogen, or C1-C6 alkyl, or R2, R3 and the carbon to which they are attached may form a carbonyl group (C═O), or a C3-C5 carbocyclic ring;
• R4 is a C6-C10 monocyclic or bicyclic aryl group or a 5 or 6 membered heteroaryl group wherein said aryl or heteroaryl group is optionally substituted with up to 5 substituents independently selected from halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C8 alkoxyalkyl, C1-C8 haloalkyl, C1-C8 hydroxyalkyl, C2-C8 alkenyl, C2-C8 alkynyl, nitrile, and nitro;
• wherein said heteroaryl ring is selected from pyrrolyl, thienyl, furanyl, thiazolyl, triazolyl, imidazolyl, (is)oxazolyl, oxadiazolyl, tetrazolyl, pyridyl, thiadiazolyl, oxadiazolyl, oxathiadiazolyl, thiatriazolyl, pyrimidinyl, quinolinyl, isoquinolinyl, napthyridinyl, phthalimidyl, benzimidazolyl, and benzoxazolyl;
• R5 is hydrogen, aryl, C1-C8 alkyl, C1-C8 alkoxy, C3-C7 cycloalkyl, C3-C8 alkenyl, C5-C8 cycloalkenyl, C6-C10 aryl, C5-C10 heteroaryl, or C3-C7-heterocyclyl;
• R6 is hydrogen, (CR7R8)nAr, (CR7R8)nheteroaryl, (CR7R3)nheterocyclyl, C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl, or C2-C10 alkynyl, wherein each of the (CR7R8)nAr, (CR7R8)nheteroaryl, alkyl, cycloalkyl, alkenyl, and alkynyl groups are optionally substituted with up to 7 groups selected from halogen, C1-C8 alkyl, C3-C7 cycloalkyl, C3-C8 cycloalkyloxy, C3-C8 heterocyclyl, C3-C8 heterocycloalkyloxy, C3-C8 heterocyclylalkyl, C1-C8 alkoxy, C1-C8 alkoxyalkyl, C1-C8 haloalkyl, C1-C8 hydroxyalkyl, C2-C8 alkenyl, C2-C8 alkynyl, phenoxy, phenyl, (CR9R10)nAr, (CR9R10)nheteroaryl, nitrile, nitro, (CR7R8)mR9, OR7, SR7, NR7R8, N(O)R7R8, P(O)(OR7)(OR8), (CR7R8)mNR9R10, (CR7R8)mC(O)N9R10, (CR7R8)mOR9, (CR7R8)mC(O)R9, (CR7R8)mCO2R9, CONR7R8, C(O)NR7SO2R8, NR7SO2R8, C(O)NR7OR8, (CR7R8)mS(O)nR9, SO2NR7R8, NR7CO2R8, NR7COR8, NR7CONR8R9, NR7SO2R8, N(O)R7R8, NR7R8R9Y, (CR7R8)mP(O)(OR9)(OR10), -T(CH2)mQR7, —C(O)T(CH2)mQR7, -T(CH2)mC(O)NR7R8, -T(CH2)mCO2R7, and NR7C(O)T(CH2)mQR7;
• wherein R6 optionally may be absent when W is a halogen;
• n is an integer of from 1 to 3;
• m is an integer of from 0 to 5;
• T is selected from the group consisting of O, S, NR9, N(O)R9, and CR9R10;
• Q is selected from the group consisting of O, S, NR9, N(O)R9, CO2, O(CH2)m-heteroaryl, O(CH2)mS(O)nR9, (CH2)-heteroaryl, and a saturated or unsaturated carbocyclic group containing from 3-7 ring members, up to four of which ring carbon atoms are optionally replaced by heteroatoms independently selected from oxygen, sulfur, and nitrogen, provided, however, that there is at least one carbon atom in the carbocyclic ring and that, if there are two or more ring oxygen atoms, the ring oxygen atoms are not adjacent to one another, wherein the heteroaryl or carbocyclic group is unsubstituted or substituted with one, two, or three groups independently selected from halogen, hydroxy, hydroxyalkyl, C1-C8 alkyl, C1-C8 alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylcarbonylamino, aminoalkyl, trifluoromethyl, N-hydroxyacetamide, trifluoromethylalkyl, amino, and mono or dialkylamino;
• R7, R8, R9 and R10 are, in each instance, independently, hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, arylalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or heterarylalkyl;
• or R7 and R8, when attached to the same nitrogen atom, taken together with the nitrogen to which they are attached, may form a saturated or unsaturated heterocyclic ring containing from 3-8 ring members, up to four of which members can optionally be replaced with heteroatoms independently selected from oxygen, sulfur, S(O), S(O)2, and nitrogen, provided, however, that there is at least one carbon atom in the heterocyclic ring and that if there are two or more ring oxygen atoms, the ring oxygen atoms are not adjacent to one another, wherein the heterocyclic group is unsubstituted or substituted with one, two or three groups independently selected from halogen, hydroxy, hydroxyalkyl, lower alkyl, lower alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylcarbonylamino, aminoalkyl, aminoalkylcarbonyl, trifluoromethyl, trifluoromethylalkyl, trifluoromethylalkylaminoalkyl, amino, nitrile, mono- or dialkylamino, N-hydroxyacetamido, aryl, heteroaryl, carboxyalkyl, NR9SO2R10, C(O)NR9R10, NR9C(O)R10, C(O)OR9, C(O)NR9SO2R10, (CH2)mS(O)nR9, (CH2)m-heteroaryl, O(CH2)m-heteroaryl, (CH2)mC(O)NR9R10, O(CH2)mC(O)OR9, and (CH2)SO2NR9R10;
• and the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof.