Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors

A medicament, which comprises, as an active compound, one or more compounds of the general formula I and/or II

• in which
• E is a group from
• B is —SO2— or —CO—,
• X is —NR1 or —CHR1,
• Z is —R4, —OR4 or —NH—R4,
• Y is —OR2or —NHR2,
• R1 is in each case independently —H, —C1-C6-alkyl, —C2-C6-alkenyl or —C2-C6-alkynyl, unsubstituted or substituted,
• R2 is —H, —OR1, —COR1, —CON(R1)2 or —COOR1,
• R3 is —H, —C1-C6-alkyl, —C2-C6-alkenyl or —C2-C6-alkynyl, unsubstituted or substituted, or —COR6 or —COOR6 or an oligo- or polyalkyleneoxy radical,
• R4 is —H, —C1-C6-alkyl, —C2-C6-alkenyl or —C2-C6-alkynyl, unsubstituted or substituted, or a cyclic radical,
• R5 is —OR6, —N(R6)2, —C1-C6-alkyl, —C2-C6-alkenyl or —C2-C6-alkynyl, unsubstituted or substituted, and
• R6 is —H, —C1-C6-alkyl, —C2-C6-alkenyl or —C2-C6-alkynyl, unsubstituted or substituted, or a cyclic radical,
• with each cyclic radical being able to carry one or more substituents selected from the group consisting of —C1-C3-alkyl, —C1-C3-alkoxy, halogen, —OR6, ═O, —NO2, —CN, —COOR6, —N(R6)2, —NR6COR6, —NR6CON(R6)2 and —OCOR6,
• and it being possible for each alkyl, alkenyl or alkynyl to be straight-chained or branched and to carry one or more substituents selected from the group consisting of halogen, —OR6, —OCOR6, —N(R6)2, —NR6COR6, —NR6CON(R6)2, COOR6 or a cyclic radical,
• or salts of said compounds and optionally pharmaceutically customary carriers, diluents or/and adjuvants.