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US 2006/0142271 A1Published application
Novel lapacho compounds and methods of use thereof
OwnerKlaus Muller, Andreas Sellmer +4inventors
InventorsKlaus Muller, Andreas Sellmer, June Salvesen, Chiang Li, Youzhi Li, Xianggao Sun
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Abstract
The invention provides new synthetic lapacho derivatives as well as methods of use thereof. These compounds can be used in pharmaceutical compositions for the treatment or prevention of cell proliferation disorders. These compounds can also be used in the treatment or prevention of psoriasis or cancer or precancerous conditions.
Claims42
A compound of formula I:
- wherein X is O or S;
- and R is straight-chained or branched C1-C6 alkyl, aryl, substituted aryl, or straight-chained or branched alkylaryl, or a pharmaceutically acceptable salt thereof;
- wherein 1) R is not methyl;
- 2) where X is O, R is not bromomethyl, unsubstituted phenyl, or phenyl substituted at the 4-position with methyl, chloro, ethenyl, or 2′-chloroethyl;
- and 3) where X is S, R is not 2-carboxyphenyl.
2 more elements
A compound of formula II:
- wherein X is O or S;
- and R is straight-chained or branched C1-C6 alkyl, aryl, substituted aryl, or straight-chained or branched alkylaryl, or a pharmaceutically acceptable salt thereof;
- wherein R is not methyl.
A compound of formula III:
- wherein X is O or S;
- R1 is independently at each incidence hydroxyl, alkoxyl, C1-C6 alkyl, nitro, halogen, carboxyl or carboxyalkyl;
- R2 is hydrogen or —C(O)—R3, R3 is straight-chained or branched C1-C6 alkyl, aryl, substituted aryl, or straight-chained or branched alkylaryl;
- and n is 0, 1 or 2;
- or a pharmaceutically acceptable salt thereof;
- wherein 1) where X is O, R2 is not H;
- 2) where X is O, and R2 is —C(O)—R3, and R3 is methyl, then R1 is not hydroxyl or methoxy;
- and 3) where X is S and R2 is H, then n is 1 and R1 is selected from —OH and —OC(O)-alkyl(C1-C6);
- and 4) where X is S and R2 is —C(O)—R3, and R3 is methyl, then R1 does not represent a 7-acetyl group.
6 more elements
Dependencies are inferred from the claim text.