Dihydro-dibenzo[b,e]oxepine based selective estrogen receptor modulators, compositions and methods

A compound of the formula

• wherein
• R1 is —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), or —OSO2(C2-C6 alkyl);
• R0a, R2a and R3a are each independently —H, —OPg, or halo, wherein Pg is a hydroxy protecting group;
• R4 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino;
• n is 2 or 3;
• G1 is —O—, —S—, or —N(R5)—, wherein R5 is —H or C1-C4 alkyl;
• and
• Y is —O—, —S—, —NH—, —NMe-, or —CH2—;
• or a pharmaceutically acceptable salt thereof.

A compound of the formula

• wherein
• R1 is —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), or —OSO2(C2-C6 alkyl);
• R0a, R2a and R3a are each independently —H, —OPg, or halo, wherein Pg is a hydroxy protecting group;
• R4 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino;
• n is 2 or 3;
• G1 is —O—, —S—, or —N(R5)—, wherein R5 is —H or C1-C4 alkyl;
• and
• Y is —O—, —S—, —NH—, —NMe-, or —CH2—;
• or a pharmaceutically acceptable salt thereof.