Water-soluble anionic bacteriochlorophyll derivatives and their uses
AssigneeYeda Research and Development Co. Ltd.
InventorsAvigdor Scherz, Yoram Salomon, Ohad Mazor, Hugo Scheer
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Abstract
The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO<−>, COS<−>, SO3<−>, PO3<2−>, COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.
Claims45
A bacteriochlorophyll derivative containing at least one, preferably two or three, negatively charged groups or acidic groups that are converted to negatively charged groups at the physiological pH, or both, excluding pentacyclic bacteriochlorophyll derivatives having a free CH2CH2COOH or a CH2CH2COO− group at position 17, and tetracyclic bacteriochlorophyll derivatives devoid of a central metal atom and having a —CH2CH2COOH group at position 17, a —CH2COOH or —COOH group at position 15, a —COOH group at position 13, methyl groups at the positions 2, 7, 12, 18, and ethyl groups at the positions 3 and 8.
Palladium 31-oxo-15-methoxycarbonylmethyl-rhodobacteriochlorin 131-(2-sulfoethyl)amide dipotassium salt.
-35. (canceled)
The compound Palladium bacteriopheophorbide a 173-(3-sulfo-1-oxysuccinimide)ester sodium salt, as an intermediate.
Dependencies are inferred from the claim text.