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US 2006/0142244 A1Published application
Geranyl compounds
AssigneeOhgen Research Laboratories, Ltd.
InventorKiyoshi Akiyama
Life of this patent
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Abstract
This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 have the significations as given in the specification.
Claims11
1-7. (canceled)
A geranyl compound represented by the following formula (I-2) or (I-3):
- in which R2 stands for a residual group remaining after removing all carboxyl groups present in a carboxylic acid selected from the group consisting of malic acid, citric acid, succinic acid, fumaric acid, 2-oxoglutaric acid, pyruvic acid, p-pyruvoaminobenzoic acid, retinoic acid, tyrosine, cysteine, glutamic acid and serine, and where hydroxyl or amino group(s) are present in the residual group, they may optionally be protected by acyl (e.g., lower alkanoyl) or benzyloxycarbonyl group(s),
- m is 1, 2 or 3,
- n is 0, 1 or 2,
- m+n show the number of carboxyl groups which are present in said carboxylic acid, and
- R3 stands for p-hydroxyphenyl or mercapto group.
2 more elements
A mevalonic acid derivative represented by the following formula (I-4):
- in which R4 stands for —CH2OH or —CH3.
Dependencies are inferred from the claim text.