Starch derivatives and other derivatives, production processes therefor, and wound healing applications therefor
AssigneeTissue Technologies Holdings, LLC
InventorsYousef Mohajer, Irwin Cohen
Life of this patent
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Abstract
Novel phosphate starch derivatives are useful in wound healing. Novel phosphorylated cottons are useful in wound healing. Silver-derivatized wound care products are provided which survive washing and remain part of the wound care product. Silver-derivatized wound care products are provided that have favorable elastase-sequestering activity while advantageously appearing white-colored, without needing to darken to grey or black as usually would occur when working with silver. Also, starch products with outstanding water uptake are provided.
Claims13
A starch derivative comprising a starch-derived compound containing a urea network, wherein the compound when exposed to water swells, at room temperature, at least 10 times dry weight.
A starch derivative having the following formula (I):
- [-St-(OPO3−H)k (OH)l(O-Z)m(O—W)p] (I)
- wherein:
- “St” means a subunit of starch;
- k+l+m+p=3;
- k is equal or less than 0.5;
- l, m, and p are numbers between zero and 3 inclusive and may be fractions;
- “Z” is selected from the group consisting of:
- C(O)NH2;
- C(S) NH2;
- C(O)NH3.A or C(S)NH3.A wherein “A” is selected from the group consisting of an anion of phosphoric acid, sulfuric acid, nitric acid, hydrochloric acid and perchloric acid);
- C(O)-St;
- and C(S)-St;
- and
- W comprises a condensation product CH2R wherein R is selected from the group consisting of:
- —NH—C(O)—NH2;
- —NH—C(O)—NH—CH2—OSt;
- —NH—C(S)—NH2;
- —NH—C(S)—NH—CH2—OSt;
- a melamine group;
- a melamine group wherein an NH2 group is attached to CH2—OSt;
- any combination thereof and any chain extended version thereof and wherein W may be substituted or unsubstituted;
- and wherein negative charge on the PO3−is neutralized by a cation.
A wound treatment product, comprising at least one of:
- (A) a starch derivative containing a urea network, wherein the starch derivative when exposed to water swells, at room temperature, at least 10 times dry weight;
- (B) a starch derivative having formula (I);
- or (C) a cotton derivative compound comprising a cotton and at least one selected from the group consisting of:
- a urea derivative;
- a thiourea derivative;
- a condensation product of urea and formaldehyde;
- and, a condensation product of thiourea and formaldehyde.
Dependencies are inferred from the claim text.