Methods and compositions for reducing neurodegeneration in amyotrophic lateral sclerosis
OwnerSeo Yooinventor
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Abstract
The present disclosure is related to clear aqueous solutions of one or more bile acids and either an aqueous soluble starch conversion product or a non-starch polysaccharide. Solutions of the disclosure may be administered to a subject in conjunction with a pharmaceutical compound having a therapeutic effect in subjects with a neurodegenerative disease and/or a motor neuron disease. In some embodiments, the disease is amyotrophic lateral sclerosis.
Claims68
A method of ameliorating or treating at least one symptom of a neurodegenerative diseases in a subject comprising:
- administering to a subject a clear aqueous solution comprising:
- (a) a first material selected from the group consisting of a bile acid, an aqueous soluble derivative of a bile acid, a bile acid salt, and a bile acid conjugated with an amine by an amide linkage;
- (b) a carbohydrate selected from the group consisting of an aqueous soluble starch conversion product or an aqueous soluble non-starch polysaccharide;
- (c) water, wherein the first material and the carbohydrate both remain in solution for all pH values of the solution within a selected range of pH values.
A method of ameliorating or treating at least one symptom of a motor neuron disease in a subject comprising:
- administering to a subject a clear aqueous solution comprising:
- (a) a first material selected from the group consisting of a bile acid, an aqueous soluble derivative of a bile acid, a bile acid salt, and a bile acid conjugated with an amine by an amide linkage;
- (b) a carbohydrate selected from the group consisting of an aqueous soluble starch conversion product or an aqueous soluble non-starch polysaccharide;
- (c) water, wherein the first material and the carbohydrate both remain in solution for all pH values of the solution within a selected range of pH values.
A method for ameliorating or treating at least one symptom of a neurodegenerative disease or at least one symptom of a motor neuron disease in a subject comprising:
- administering a pharmaceutical compound to the subject;
- and
- administering to the subject a clear aqueous solution comprising:
- (a) a first material selected from the group consisting of a bile acid, an aqueous soluble derivative of a bile acid, a bile acid salt, and a bile acid conjugated with an amine by an amide linkage;
- (b) a carbohydrate selected from the group consisting of an aqueous soluble starch conversion product or an aqueous soluble non-starch polysaccharide;
- (c) water, wherein the first material and the carbohydrate both remain in solution for all pH values of the solution within a selected range of pH values;
A clear aqueous solution comprising:
- (a) a first material selected from the group consisting of a bile acid, an aqueous soluble derivative of a bile acid, a bile acid salt, and a bile acid conjugated with an amine by an amide linkage;
- (b) a carbohydrate selected from the group consisting of an aqueous soluble starch conversion product or an aqueous soluble non-starch polysaccharide;
- (c) a pharmaceutically effective amount of a pharmaceutical compound that decreases motor neuron death;
- and
- (d) water,
- wherein the first material, the carbohydrate, and the riluzole all remain in solution for all pH values of the solution within a selected range of pH values.
Dependencies are inferred from the claim text.