Method of reducing and treating UVB-induced immunosuppression

A method of restoring at least a portion of diminished contact hypersensitivity, the method comprising administering to a subject at risk for diminished contact hypersensitivity an immune response modifier compound in an amount effective to restore at least a portion of the diminished contact hypersensitivity,

• wherein the immune response modifier compound is selected from the group consisting of:
• an imidazoquinoline amine, an imidazopyridine amine, a 6,7-fused cycloalkylimidazopyridine amine, a 1,2-bridged imidazoquinoline amine, an imidazonaphthyridine amine, an imidazotetrahydronaphthyridine amine, an oxazoloquinoline amine, a thiazoloquinoline amine, an oxazolopyridine amine, a thiazolopyridine amine, an oxazolonaphthyridine amine, a thiazolonaphthyridine amine, and a CpG oligonucleotide.