Oligomeric compositions and methods
AssigneeIsis Pharmaceuticals, Inc.
InventorsGarth Kinberger, Martin Maier, Richard Griffey, Eric Swazye
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Abstract
The activated oligomer compounds described herein are capable of forming bio-reversible covalent bonds with plasma proteins, in particular with human serum albumin. The plasma protein-oligomer complexes of the present invention exhibit enhanced cellular entry and significantly enhanced serum half-life.
Claims24
A method of treating a subject with an activated oligomer, the method comprising:
- a. providing an activated oligomer, said activated oligomer conjugated optionally with a bivalent linking group to an activated disulfide moiety;
- and
- b. administering the activated oligomer to said subject.
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-20. (canceled)
The method of claim 21, wherein R1 is selected from 2-pyridyl, 3-nitro-2pyridyl, 5-nitro-2-pyridyl, 2-benzothiazolyl, N-(C1-C12 alkyl)-2-pyridyl, N-oxide-2-pyridyl, or 1-methyl-2-1H-tetrazolyl.
-115. (canceled)
Dependencies are inferred from the claim text.