Double-stranded ribonucleic acid molecules having ribothymidine
AssigneeNastech Pharmaceutical Company Inc.
InventorSteven Quay
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Abstract
The invention relates to a double-stranded RNA (dsRNA) molecule comprising between about 15 base pairs and about 40 base pairs, wherein at least one ribonucleotide of the dsRNA is a 5′-methyl-pyrimidine, and a method of using such modified dsRNA molecule to increase stability of RNA when in contact with a biological sample.
Claims21
A double-stranded RNA (dsRNA) molecule comprising between about 15 base pairs and about 40 base pairs, wherein at least one ribonucleotide of the dsRNA is a 5′-methyl-pyrimidine.
A method of improving ribonuclease stability of a double stranded siRNA molecule when the siRNA is contacted with a biological sample, by preparing a siRNA molecule wherein at least one uridine of the siRNA sequence is replaced by a ribothymidine and forming a double stranded siRNA molecule.
Dependencies are inferred from the claim text.