Back to results
US 2006/0142228 A1Published application
Methods and compositions concerning siRNA's as mediators of RNA interference
AssigneeAmbion, Inc.
InventorsLance Ford, Joseph Krebs
Life of this patent
Estimating the term…
Abstract
The present invention concerns an isolated siRNA of from about 5 to about 20 nucleotides that mediates RNA interference. Also disclosed are methods of reducing expression of a target gene in a cell comprising obtaining at least one siRNA of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 basepairs in length; and delivering the siRNA into the cell. The siRNAs can be chemically synthesized RNA or an analog of a naturally occurring RNA.
Claims41
An isolated RNA of from about 5 to about 20 nucleotides that mediates RNA interference of a target mRNA.
A method of reducing expression of a target gene in a cell comprising:
- a) obtaining at least one siRNA of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 nucleotides in length;
- and
- b) delivering the siRNA into the cell.
Dependencies are inferred from the claim text.