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US 2006/0142227 A1Published application
Amphiphylic peptide-PNA conjugates for the delivery of PNA through the blood brain barrier
OwnerItschak Lamensdorf, Jehoshua Katzhendlerinventors
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Abstract
The invention provides molecules comprising a nucleic acid, a hydrophobic moiety and a positively charge moiety, useful in the delivery of a nucleic acid sequence across a cellular membrane. The invention further relates to the use of these molecules for the delivery of a nucleic acid sequence to the brain across the blood brain barrier for diagnostic and therapeutic applications.
Claims26
A molecule represented by any one of the formulas I-IV:
- [(H)q—(N)r—(P)s]x I.
- [(N)r—(H)q—(P)s]x II.
- [(P)s—(H)q—(N)r]x III.
- [(N)r,(P)s—(H)q]x IV.
- wherein N is a nucleic acid sequence in a length of 1-100 bases, H is a hydrophobic moiety and P is a positively charge moiety;
- and
- wherein q is an integer of 1-20, r is an integer of 0-20, s is an integer of 1-25 and x is an integer of 1-20.
4 more elements
Dependencies are inferred from the claim text.