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US 2006/0142224 A1Published application
Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
AssigneeIdera Pharmaceuticals, Inc.
InventorsEkambar Kandimalla, Qiuyan Zhao, Dong Yu, Sudhir Agrawal
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Abstract
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
Claims5
1-19. (canceled)
An immunostimulatory oligonucleotide compound, comprising:
- an immunostimulatory dinucleotide of formula 5′-pyrimidine-purine-3′, wherein pyrimidine is a natural or non-natural pyrimidine nucleoside and purine is a natural or non-natural purine nucleoside;
- a 3′-3′ linkage;
- and
- one or two accessible 5′ ends;
- provided that the oligonucleotide is not complementary to the gag or tat gene of HIV-1.
2 more elements
23-38. (canceled)
Dependencies are inferred from the claim text.