Loading patent…
OwnerMakoto Ogino, Tomohiro Hirose +3inventors
InventorsMakoto Ogino, Tomohiro Hirose, Kazumi Hayashi, Tomonobu Koizumi, Toshihide Yokoyama
Estimating the term…
This discloses a novel human or rat polypeptide useful in improving and/or preventing organ fibrosis and a polynucleotide encoding the aforementioned polypeptide, an expression vector containing the aforementioned polynucleotide, and a cell transfected with the aforementioned expression vector. The aforementioned polynucleotide shows a remarkable decrease in the expression dose in the kidney of a chronic renal insufficiency model rat and in the bladder of a rat suffering from the induction of fibrotic conditions in the bladder, compared with a normal individual. Also, the production of extracellular matrix is suppressed by overexpression of the aforementioned polypeptide. Also disclosed are the promoter region of the aforementioned polypeptide, a method for screening a remedy for fibrotic conditions, and a process for producing a medicinal composition for improving fibrotic conditions which contains a substance obtained by the aforementioned screening method as the active ingredient.
A polypeptide which comprises the amino acid sequence represented by SEQ ID NO:2 or SEQ ID NO:4 and which suppresses expression of type I collagen, fibronectin and/or MCP-1, or a polypeptide which comprises an amino acid sequence, represented by SEQ ID NO:2 or SEQ ID NO:4 wherein from 1 to 10 amino acids of the amino acid sequence are deleted, substituted and/or inserted and which suppresses expression of type I collagen, fibronectin and/or MCP-1.
A polypeptide which comprises the amino acid sequence represented by SEQ ID NO:2 or SEQ ID NO:4.
A polypeptide which comprises an amino acid sequence represented by the 1st to 166th positions of the amino acid sequence represented by SEQ ID NO:2, or a polypeptide which comprises an amino acid sequence represented by the 1st to 166th positions of the amino acid sequence represented by SEQ ID NO:2 wherein from 1 to 10 amino acids of an amino acid sequence are deleted, substituted and/or inserted, and which suppresses expression of type I collagen, fibronectin and/or MCP-1.
A medicinal composition for improving and/or preventing fibrosis, which contains a polypeptide described in any one of the following (a) to (c) as the active ingredient;
A polynucleotide which comprises (1) the nucleotide sequence represented by SEQ ID NO:23, or (2) a nucleotide sequence represented by the 1124th to 1525th positions of the nucleotide sequence represented by SEQ ID NO:23.
Dependencies are inferred from the claim text.