Protein modification
OwnerPatrick Berkel, Maurice Mannesse +1inventors
InventorsPatrick Berkel, Maurice Mannesse, Frank Pieper
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Abstract
The present invention relates to a method for changing the half-life of a glycosylated compound by the modification of its O-linked carbohydrates. This modification is preferably carried out enzymatically and aimed at extending the half-life of the compound. Both in vivo and in vitro modification protocols may be used.
Claims21
C1 inhibitor which is characterised in that its plasma circulatory half-life has been changed by modification of an O-linked carbohydrate.
14-15. (canceled)
A method for extending the blood circulatory half-life of a glycoprotein or of a glycoprotein comprising compound, wherein the method comprises removing one or more non sialylated O-linked carbohydrates from the glycoprotein.
Dependencies are inferred from the claim text.