Methods for treating neuropathological states and neurogenic inflammatory states and methods for identifying compounds useful therein
AssigneeBoard of Regents, The University of Texas System
InventorsKarin High, Giulio Taglialatela
Life of this patent
Estimating the term…
Abstract
The present invention provides methods for treating neuropathological states and neurogenic inflammatory states in a subject. The present invention also provides methods for identifying compounds that can be used to treat such states. Preferably, the compounds alter the distribution of NMDA glutamate receptor NR1 subunit in cells, and/or alter the production of TNFα by cells.
Claims22
A method for treating a neuropathological state in a subject, the method comprising:
- administering to the subject an effective amount of a tyrosine kinase inhibitor.
(canceled)
A method for treating a neuropathological state in a subject, the method comprising:
- administering to the subject an effective amount of a compound that decreases the amount of NR1 subunit associated with a nucleus of a cell of the subject, wherein the cell comprises an NMDA glutamate receptor.
(canceled)
A method for treating a neuropathological state in a subject, the method comprising:
- administering to the subject an effective amount of a compound that decreases the amount of Tumor Necrosis Factor α (TNFα) produced by a cell of the subject, wherein the cell comprises an NMDA glutamate receptor.
18-24. (canceled)
A method for treating a neurogenic inflammatory state in a subject, the method comprising:
- administering to the subject an effective amount of a compound that decreases the amount of TNFα produced by a cell of the subject, wherein the cell comprises an NMDA glutamate receptor.
28-31. (canceled)
Dependencies are inferred from the claim text.