Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture

A glucopyranosyl-substituted benzene derivative selected from among:

• (1) 1-Methyl-2-(4-cyclopentyloxy-benzyl)-4-(β-D-glucopyranos1-yl)-benzene,
• (2) 1-Methyl-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene,
• (3) 1-Methyl-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene,
• (4) 1-Methyl-2-(4-cyclohexyloxy-benzyl)-4-(β-D-glucopyranos1-yl)-benzene,
• (5) 1-Chloro-2-[4-(1-tert-butyloxycarbonylpiperidin-4-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene,
• (6) 1-Chloro-2-[4-(piperdin-4-yloxy)-benzyl]-4-(β-D-glucopyranos1-yl)-benzene,
• (7) 1-Methoxy-2-(β-D-glucopyranos1-yl)-4-(4-ethynyl-benzyl)-benzene,
• (8) 1-Chloro-2-(4-methoxymethylethynyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene,
• (9) 1-Chloro-2-(4-hydroxymethylethynyl-benzyl)-4-(β-D-glucopyranos1-yl)-benzene,
• (10) 1-Chloro-2-(4-hydroxyethylethynyl-benzyl)-4-(β-D-glucopyranos1-yl)-benzene,
• (11) 1-Ethynyl-2-(4-methoxy-benzyl)-4-(β-D-glucopyranos1-yl)-benzene,
• (12) 1-Methyl-2-(4-butyn-1-yl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene,
• (13) 1-Chloro-2-(4-propyn1-yl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene,
• (14) 1-Methyl-2-(4-propyn1-yl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene,
• (15) 1-Isopropyl-2-(4-ethynyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene,
• (16) 1-Chloro-2-(4-isopropylethynyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene,
• or a derivative thereof wherein one or more hydroxyl groups of the β-D-glucopyranosyl group are acylated with groups selected from (C1-18-alkyl)carbonyl, (C1-18-alkyl)oxycarbonyl, phenylcarbonyl and phenyl-(C1-3-alkyl)-carbonyl, or a pharmaceutically acceptable salt thereof;
• including the tautomers, the stereoisomers thereof or the mixtures thereof, and salts thereof.