Glucopyranosyloxypyrazole derivatives and medicinal use thereof

A glucopyranosyloxypyrazole derivative represented by the general formula:

• wherein one of Q and T represents a group represented by the general formula:
• wherein P represents a hydrogen atom or a group forming prodrug;
• the other represents a lower alkyl group or a halo(lower alkyl) group;
• R11 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkyl-substituted (lower alkyl) group, a group forming prodrug or a group represented by the general formula:
• P1-0-A1- wherein P1 represents a hydrogen atom or a group forming prodrug;
• and A1 represents a lower alkylene group;
• R12 represents a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, a cyclic lower alkylidenemethyl group, a phenyl group which may have 1-3 different or same groups selected from a halogen atom and a hydroxy group, a 5- or 6-membered aromatic heterocyclic group which contains 1-4 different or same atoms selected from an oxygen atom, a sulfur atom and a nitrogen atom in the ring, or a group represented by the general formula:
• P2—O—A2— wherein P2 represents a hydrogen atom or a group forming prodrug;
• and A2 represents a lower alkylene group;
• and with the proviso that at least one of P, R11 and R12 has a group forming prodrug, or a pharmaceutically acceptable salt thereof.

A glucopyranosyloxypyrazole derivative represented by the general

• formula:
• wherein one of Q1 and T1 represents a group represented by the general formula:
• wherein P represents a hydrogen atom or a group forming prodrug;
• the other represents a lower alkyl group or a halo(lower alkyl) group;
• R11 represents a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkyl-substituted (lower alkyl) group, a group forming prodrug or a group represented by the general formula:
• P1—O—A1— wherein P1 represents a hydrogen atom or a group forming prodrug;
• and A1 represents a lower alkylene group;
• R12 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group, or a halogen atom;
• and with the proviso that at least one of P, R11 and R12 has a group forming prodrug and R11 represents a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof.